Deciphering the somite segmentation clock: Beyond mutants and morphants

Julian Lewis, Ertuǧrul M. Özbudak

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The regular pattern of somite segmentation depends on a clock, the somite segmentation clock, in the form of a gene expression oscillator, operating in the presomitic mesoderm (the PSM) at the tail end of the vertebrate embryo. Genetic screens and other approaches have identified a variety of genes, including components and targets of the Notch signalling pathway, that show transcriptional oscillations in this region and appear to be necessary for correct segmentation. Mathematical modelling shows that the oscillations could plausibly be generated by a simple mechanism of delayed negative feedback, based on autoinhibition of Notch target genes of the Hes/her family by their own protein products. To move beyond plausible models to an experimentally validated theory, however, it is necessary to measure the parameters on which the proposed model is based and to devise ways of probing the dynamics of the system by means of timed disturbances so as to compare with the model's predictions. Some progress is being made in these directions.

Original languageEnglish (US)
Pages (from-to)1410-1415
Number of pages6
JournalDevelopmental Dynamics
Volume236
Issue number6
DOIs
StatePublished - Jun 1 2007

Keywords

  • Gene expression dynamics
  • Her genes
  • Hes genes
  • Mathematical modeling
  • Notch pathway
  • Oscillation
  • Segmentation clock
  • Synchronization

ASJC Scopus subject areas

  • Developmental Biology

Fingerprint Dive into the research topics of 'Deciphering the somite segmentation clock: Beyond mutants and morphants'. Together they form a unique fingerprint.

  • Cite this