Dealing with low pH: entry and exit of alphaviruses and flaviviruses

Claudia Sánchez San Martín, Catherine Y. Liu, Margaret Kielian

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The alphaviruses and flaviviruses include many important human pathogens, such as the dengue, West Nile, and Chikungunya viruses. These enveloped viruses infect cells by a membrane fusion reaction triggered by the low pH in endosomes. Fusion is mediated by viral membrane proteins through their acid-dependent conversion from a dimer on the virus surface to a homotrimer inserted into the host cell membrane. Here we review recent studies on the regulatory mechanisms that silence these fusion proteins during virus exit and that sense low pH and mediate protein refolding during virus entry. We discuss results using truncated proteins to dissect the fusion reaction, and future research directions including the development of antiviral therapies against these medically important viruses.

Original languageEnglish (US)
Pages (from-to)514-521
Number of pages8
JournalTrends in Microbiology
Volume17
Issue number11
DOIs
StatePublished - Nov 2009

Fingerprint

Alphavirus
Flavivirus
Viruses
Viral Matrix Proteins
Chikungunya virus
Cell Membrane
Viral Fusion Proteins
Protein Refolding
West Nile virus
Virus Internalization
Membrane Fusion
Dengue
Endosomes
Antiviral Agents
Acids
Proteins
Therapeutics

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

Cite this

Dealing with low pH : entry and exit of alphaviruses and flaviviruses. / Martín, Claudia Sánchez San; Liu, Catherine Y.; Kielian, Margaret.

In: Trends in Microbiology, Vol. 17, No. 11, 11.2009, p. 514-521.

Research output: Contribution to journalArticle

Martín, Claudia Sánchez San ; Liu, Catherine Y. ; Kielian, Margaret. / Dealing with low pH : entry and exit of alphaviruses and flaviviruses. In: Trends in Microbiology. 2009 ; Vol. 17, No. 11. pp. 514-521.
@article{0f15cc6675344102b5d2a394cda5b30a,
title = "Dealing with low pH: entry and exit of alphaviruses and flaviviruses",
abstract = "The alphaviruses and flaviviruses include many important human pathogens, such as the dengue, West Nile, and Chikungunya viruses. These enveloped viruses infect cells by a membrane fusion reaction triggered by the low pH in endosomes. Fusion is mediated by viral membrane proteins through their acid-dependent conversion from a dimer on the virus surface to a homotrimer inserted into the host cell membrane. Here we review recent studies on the regulatory mechanisms that silence these fusion proteins during virus exit and that sense low pH and mediate protein refolding during virus entry. We discuss results using truncated proteins to dissect the fusion reaction, and future research directions including the development of antiviral therapies against these medically important viruses.",
author = "Mart{\'i}n, {Claudia S{\'a}nchez San} and Liu, {Catherine Y.} and Margaret Kielian",
year = "2009",
month = "11",
doi = "10.1016/j.tim.2009.08.002",
language = "English (US)",
volume = "17",
pages = "514--521",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Dealing with low pH

T2 - entry and exit of alphaviruses and flaviviruses

AU - Martín, Claudia Sánchez San

AU - Liu, Catherine Y.

AU - Kielian, Margaret

PY - 2009/11

Y1 - 2009/11

N2 - The alphaviruses and flaviviruses include many important human pathogens, such as the dengue, West Nile, and Chikungunya viruses. These enveloped viruses infect cells by a membrane fusion reaction triggered by the low pH in endosomes. Fusion is mediated by viral membrane proteins through their acid-dependent conversion from a dimer on the virus surface to a homotrimer inserted into the host cell membrane. Here we review recent studies on the regulatory mechanisms that silence these fusion proteins during virus exit and that sense low pH and mediate protein refolding during virus entry. We discuss results using truncated proteins to dissect the fusion reaction, and future research directions including the development of antiviral therapies against these medically important viruses.

AB - The alphaviruses and flaviviruses include many important human pathogens, such as the dengue, West Nile, and Chikungunya viruses. These enveloped viruses infect cells by a membrane fusion reaction triggered by the low pH in endosomes. Fusion is mediated by viral membrane proteins through their acid-dependent conversion from a dimer on the virus surface to a homotrimer inserted into the host cell membrane. Here we review recent studies on the regulatory mechanisms that silence these fusion proteins during virus exit and that sense low pH and mediate protein refolding during virus entry. We discuss results using truncated proteins to dissect the fusion reaction, and future research directions including the development of antiviral therapies against these medically important viruses.

UR - http://www.scopus.com/inward/record.url?scp=70350340830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350340830&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2009.08.002

DO - 10.1016/j.tim.2009.08.002

M3 - Article

C2 - 19796949

AN - SCOPUS:70350340830

VL - 17

SP - 514

EP - 521

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 11

ER -