D-lactic acidosis mediated neuronal encephalopathy in acute lymphoblastic leukemia patient: An under diagnosis

Damodara Rao Mendu, Martin Fleisher, Samuel I. McCash, Melissa S. Pessin, Lakshmi V. Ramanathan

Research output: Contribution to journalArticle

5 Scopus citations


Background: D-lactic acidosis, also referred as D-lactate encephalopathy, has been reported in patients with short bowl syndrome (SBS). Case report: The neurologic symptoms include altered mental status, slurred speech, and ataxia. Onset of neurological symptoms is accompanied by metabolic acidosis and high anion gap. We present here a case of D-lactic acidosis in a patient with acute lymphoblastic leukemia (ALL) who developed severe neurological symptoms and metabolic acidosis due to vancomycin-resistant enterococci (VRE) infection, and elevated D-lactic acid.

Original languageEnglish (US)
Pages (from-to)90-91
Number of pages2
JournalClinica Chimica Acta
Publication statusPublished - Feb 4 2015



  • D-lactic acid
  • Hematological malignancy
  • Neuropathy

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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