Cytokine production and its manipulation by vasoactive drugs

S. M. Pastores, G. Hasko, E. S. Vizi, Vladimir Kvetan

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The management of severe sepsis includes the use of agonists of α- and β-adrenergic, as well as of dopaminergic, receptors. Data suggest that the severe inflammatory immune response seen in sepsis can be modulated by stimulation and inhibition of these receptors both in vitro and in vivo. Specifically, release of tumor necrosis factor and interleukins can clearly be modified. Thus, pharmacologic agents directed at circulatory support may have significant potential for immunomodulation. Since the vasopressor and inotrope support of sepsis is not well standardized, variability in the resulting inflammatory mediator response may have consequences to the efficacy of new immunotherapies. This article provides an overview of the effect of the sympathetic nervous system activity and of receptor manipulation on cytokine response to endotoxin, and adds to the perspective on inhibition of phosphodiesterase in the therapy of septic shock.

Original languageEnglish (US)
Pages (from-to)252-264
Number of pages13
JournalNew Horizons: Science and Practice of Acute Medicine
Volume4
Issue number2
StatePublished - 1996

Fingerprint

Sepsis
Cytokines
Pharmaceutical Preparations
Adrenergic Agonists
Immunomodulation
Interleukins
Sympathetic Nervous System
Phosphoric Diester Hydrolases
Septic Shock
Endotoxins
Immunotherapy
Tumor Necrosis Factor-alpha
Therapeutics
In Vitro Techniques

Keywords

  • adrenergic receptors
  • cytokines
  • dopaminergic receptors
  • immunomodulation
  • phosphodiesterase
  • sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Cytokine production and its manipulation by vasoactive drugs. / Pastores, S. M.; Hasko, G.; Vizi, E. S.; Kvetan, Vladimir.

In: New Horizons: Science and Practice of Acute Medicine, Vol. 4, No. 2, 1996, p. 252-264.

Research output: Contribution to journalArticle

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