Cytokine and Chemokine Gene Polymorphisms among Ethnically Diverse North Americans with HIV-1 Infection

Chengbin Wang, Wei Song, Elena Lobashevsky, Craig M. Wilson, Steven D. Douglas, Joannis Mytilineos, Ellie E. Schoenbaum, Jianming Tang, Richard A. Kaslow

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Twenty-four common single nucleotide polymorphisms (SNPs) in 10 cytokine and chemokine genes were defined in 579 North Americans at high risk of HIV-1 infection due to sexual behavior and injection drug use. Among the 3 major ethnic (African-American, Hispanic/Latino, and other) groups involved, HIV-1-seropositive individuals differed significantly from ethnically matched HIV-1-seronegative individuals (odds ratios = 2.13-4.82; P = 0.003-0.05) for several SNPs and haplotypes defined at the IL4, IL4R, IL6, ILIO, CCL5 (RANTES), and CXCLI2 (SDFI) loci. In addition, the homozygous IL4-590T/T genotype was associated with higher (+87-131 cells/μL) CD4+ T-cell counts in HIV-1-infected and AIDS-free adolescents not receiving antiretroviral therapy (adjusted P = 0.004). No SNPs at IFNG, IL2, ILI2B, TNF, or CCL2 (MCP1) showed any association with HIV-related outcomes. Additional typing for IL1A, IL1B, IL1R1, IL1RN, and TGFBI SNPs also failed to demonstrate any influence on HIV-1 infection or virologic/immunologic control in more selected patient groups. Coupled with previous findings, our data suggest that heritable IL4 and IL10 variations may contribute to the acquisition or progression of HIV infection and that the effects of other targeted loci in the cytokine and chemokine system cannot be established unequivocally in the study populations.

Original languageEnglish (US)
Pages (from-to)446-454
Number of pages9
JournalJournal of Acquired Immune Deficiency Syndromes
Volume35
Issue number5
DOIs
StatePublished - Apr 15 2004

Keywords

  • Allele
  • Chemokine
  • Cytokine
  • Genetics
  • HIV-1
  • Infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Cytokine and Chemokine Gene Polymorphisms among Ethnically Diverse North Americans with HIV-1 Infection'. Together they form a unique fingerprint.

Cite this