Abstract
Cancer is a genetic disease that could develop either from a predisposing mutation followed by acquired somatic mutations or from an accumulation of somatic mutations that develop into a cancer phenotype. Many different types of DNA alteration have been reported in cancer, with some of the recognized forms being as follows: Subtle DNA or RNA alterations DNA methylation Changes in chromosome number (aneuploidy) Loss of heterozygosity Chromosome translocations in somatic cells rather than in germ cells Gene amplification Incorporation of exogenous sequences
| Original language | English (US) |
|---|---|
| Title of host publication | The Principles of Clinical Cytogenetics |
| Publisher | Humana Press Inc. |
| Pages | 365-420 |
| Number of pages | 56 |
| ISBN (Print) | 9781592598335, 9781588293008 |
| DOIs | |
| State | Published - 2005 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Cytogenetics of hematologic neoplasms. / Naeem, Rizwan C.
The Principles of Clinical Cytogenetics. Humana Press Inc., 2005. p. 365-420.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Cytogenetics of hematologic neoplasms
AU - Naeem, Rizwan C.
PY - 2005
Y1 - 2005
N2 - Cancer is a genetic disease that could develop either from a predisposing mutation followed by acquired somatic mutations or from an accumulation of somatic mutations that develop into a cancer phenotype. Many different types of DNA alteration have been reported in cancer, with some of the recognized forms being as follows: Subtle DNA or RNA alterations DNA methylation Changes in chromosome number (aneuploidy) Loss of heterozygosity Chromosome translocations in somatic cells rather than in germ cells Gene amplification Incorporation of exogenous sequences
AB - Cancer is a genetic disease that could develop either from a predisposing mutation followed by acquired somatic mutations or from an accumulation of somatic mutations that develop into a cancer phenotype. Many different types of DNA alteration have been reported in cancer, with some of the recognized forms being as follows: Subtle DNA or RNA alterations DNA methylation Changes in chromosome number (aneuploidy) Loss of heterozygosity Chromosome translocations in somatic cells rather than in germ cells Gene amplification Incorporation of exogenous sequences
UR - http://www.scopus.com/inward/record.url?scp=33745247408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745247408&partnerID=8YFLogxK
U2 - 10.1385/1-59259-833-1:365
DO - 10.1385/1-59259-833-1:365
M3 - Chapter
AN - SCOPUS:33745247408
SN - 9781592598335
SN - 9781588293008
SP - 365
EP - 420
BT - The Principles of Clinical Cytogenetics
PB - Humana Press Inc.
ER -