Cytogenetics of hematologic neoplasms

Rizwan C. Naeem

doi:10.1385/1-59259-833-1:365

Cytogenetics of hematologic neoplasms

Rizwan C. Naeem

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Cancer is a genetic disease that could develop either from a predisposing mutation followed by acquired somatic mutations or from an accumulation of somatic mutations that develop into a cancer phenotype. Many different types of DNA alteration have been reported in cancer, with some of the recognized forms being as follows: Subtle DNA or RNA alterations DNA methylation Changes in chromosome number (aneuploidy) Loss of heterozygosity Chromosome translocations in somatic cells rather than in germ cells Gene amplification Incorporation of exogenous sequences

Original language	English (US)
Title of host publication	The Principles of Clinical Cytogenetics
Publisher	Humana Press Inc.
Pages	365-420
Number of pages	56
ISBN (Electronic)	9781592598335
ISBN (Print)	9781588293008
DOIs	https://doi.org/10.1385/1-59259-833-1:365
State	Published - Jan 1 2005
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Cancer is a genetic disease that could develop either from a predisposing mutation followed by acquired somatic mutations or from an accumulation of somatic mutations that develop into a cancer phenotype. Many different types of DNA alteration have been reported in cancer, with some of the recognized forms being as follows: Subtle DNA or RNA alterations DNA methylation Changes in chromosome number (aneuploidy) Loss of heterozygosity Chromosome translocations in somatic cells rather than in germ cells Gene amplification Incorporation of exogenous sequences",

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