Abstract
Cancer is a genetic disease that could develop either from a predisposing mutation followed by acquired somatic mutations or from an accumulation of somatic mutations that develop into a cancer phenotype. Many different types of DNA alteration have been reported in cancer, with some of the recognized forms being as follows: Subtle DNA or RNA alterations DNA methylation Changes in chromosome number (aneuploidy) Loss of heterozygosity Chromosome translocations in somatic cells rather than in germ cells Gene amplification Incorporation of exogenous sequences
| Original language | English (US) |
|---|---|
| Title of host publication | The Principles of Clinical Cytogenetics |
| Publisher | Humana Press Inc. |
| Pages | 365-420 |
| Number of pages | 56 |
| ISBN (Electronic) | 9781592598335 |
| ISBN (Print) | 9781588293008 |
| DOIs | |
| State | Published - Jan 1 2005 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Naeem, R. C. (2005). Cytogenetics of hematologic neoplasms. In The Principles of Clinical Cytogenetics (pp. 365-420). Humana Press Inc.. https://doi.org/10.1385/1-59259-833-1:365