Cytogenetics of hematologic neoplasms

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Cancer is a genetic disease that could develop either from a predisposing mutation followed by acquired somatic mutations or from an accumulation of somatic mutations that develop into a cancer phenotype. Many different types of DNA alteration have been reported in cancer, with some of the recognized forms being as follows: Subtle DNA or RNA alterations DNA methylation Changes in chromosome number (aneuploidy) Loss of heterozygosity Chromosome translocations in somatic cells rather than in germ cells Gene amplification Incorporation of exogenous sequences

Original languageEnglish (US)
Title of host publicationThe Principles of Clinical Cytogenetics
PublisherHumana Press Inc.
Pages365-420
Number of pages56
ISBN (Electronic)9781592598335
ISBN (Print)9781588293008
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Naeem, R. C. (2005). Cytogenetics of hematologic neoplasms. In The Principles of Clinical Cytogenetics (pp. 365-420). Humana Press Inc.. https://doi.org/10.1385/1-59259-833-1:365