Cytogenetic findings in primary uveal melanoma

Arun D. Singh, Leslie Boghosian-Sell, Kishore K. Wary, Carol L. Shields, Patrick De Potter, Larry A. Donoso, Jerry A. Shields, Linda A. Cannizzaro

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


We analyzed cytogenetic abnormalities in 10 cases of primary uveal melanoma. Clonal chromosomal abnormalities were present in nine cases. Chromosome 6 was most commonly affected (seven cases) and included gain of material from 6 and/or loss of material from 6q. Trisomy of chromosome 8 or gain in material from 8q, mostly in the form of an i(8q) resulting in three to five copies of the 8q segment was seen in six cases. Monosomy of chromosome 3 and rearrangements of chromosome 9 were less frequent and were altered in three cases each. Clinical, histopathologic, and cytogenetic abnormalities are correlated.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalCancer Genetics and Cytogenetics
Issue number2
StatePublished - Feb 1994

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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