Cytogenetic findings in primary uveal melanoma

Arun D. Singh, Leslie Boghosian-Sell, Kishore K. Wary, Carol L. Shields, Patrick De Potter, Larry A. Donoso, Jerry A. Shields, Linda A. Cannizzaro

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We analyzed cytogenetic abnormalities in 10 cases of primary uveal melanoma. Clonal chromosomal abnormalities were present in nine cases. Chromosome 6 was most commonly affected (seven cases) and included gain of material from 6 and/or loss of material from 6q. Trisomy of chromosome 8 or gain in material from 8q, mostly in the form of an i(8q) resulting in three to five copies of the 8q segment was seen in six cases. Monosomy of chromosome 3 and rearrangements of chromosome 9 were less frequent and were altered in three cases each. Clinical, histopathologic, and cytogenetic abnormalities are correlated.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume72
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

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Cytogenetics
Chromosome Aberrations
Monosomy
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 3
Uveal melanoma
Trisomy Chromosome 8

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Singh, A. D., Boghosian-Sell, L., Wary, K. K., Shields, C. L., De Potter, P., Donoso, L. A., ... Cannizzaro, L. A. (1994). Cytogenetic findings in primary uveal melanoma. Cancer Genetics and Cytogenetics, 72(2), 109-115. https://doi.org/10.1016/0165-4608(94)90125-2

Cytogenetic findings in primary uveal melanoma. / Singh, Arun D.; Boghosian-Sell, Leslie; Wary, Kishore K.; Shields, Carol L.; De Potter, Patrick; Donoso, Larry A.; Shields, Jerry A.; Cannizzaro, Linda A.

In: Cancer Genetics and Cytogenetics, Vol. 72, No. 2, 1994, p. 109-115.

Research output: Contribution to journalArticle

Singh, AD, Boghosian-Sell, L, Wary, KK, Shields, CL, De Potter, P, Donoso, LA, Shields, JA & Cannizzaro, LA 1994, 'Cytogenetic findings in primary uveal melanoma', Cancer Genetics and Cytogenetics, vol. 72, no. 2, pp. 109-115. https://doi.org/10.1016/0165-4608(94)90125-2
Singh AD, Boghosian-Sell L, Wary KK, Shields CL, De Potter P, Donoso LA et al. Cytogenetic findings in primary uveal melanoma. Cancer Genetics and Cytogenetics. 1994;72(2):109-115. https://doi.org/10.1016/0165-4608(94)90125-2
Singh, Arun D. ; Boghosian-Sell, Leslie ; Wary, Kishore K. ; Shields, Carol L. ; De Potter, Patrick ; Donoso, Larry A. ; Shields, Jerry A. ; Cannizzaro, Linda A. / Cytogenetic findings in primary uveal melanoma. In: Cancer Genetics and Cytogenetics. 1994 ; Vol. 72, No. 2. pp. 109-115.
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