Cytogenetic findings in primary uveal melanoma

Arun D. Singh, Leslie Boghosian-Sell, Kishore K. Wary, Carol L. Shields, Patrick De Potter, Larry A. Donoso, Jerry A. Shields, Linda A. Cannizzaro

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

We analyzed cytogenetic abnormalities in 10 cases of primary uveal melanoma. Clonal chromosomal abnormalities were present in nine cases. Chromosome 6 was most commonly affected (seven cases) and included gain of material from 6 and/or loss of material from 6q. Trisomy of chromosome 8 or gain in material from 8q, mostly in the form of an i(8q) resulting in three to five copies of the 8q segment was seen in six cases. Monosomy of chromosome 3 and rearrangements of chromosome 9 were less frequent and were altered in three cases each. Clinical, histopathologic, and cytogenetic abnormalities are correlated.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume72
Issue number2
DOIs
StatePublished - Feb 1994

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Singh, A. D., Boghosian-Sell, L., Wary, K. K., Shields, C. L., De Potter, P., Donoso, L. A., Shields, J. A., & Cannizzaro, L. A. (1994). Cytogenetic findings in primary uveal melanoma. Cancer Genetics and Cytogenetics, 72(2), 109-115. https://doi.org/10.1016/0165-4608(94)90125-2