Cytogenetic findings in primary uveal melanoma

Arun D. Singh; Leslie Boghosian-Sell; Kishore K. Wary; Carol L. Shields; Patrick De Potter; Larry A. Donoso; Jerry A. Shields; Linda A. Cannizzaro

doi:10.1016/0165-4608(94)90125-2

Cytogenetic findings in primary uveal melanoma

Arun D. Singh, Leslie Boghosian-Sell, Kishore K. Wary, Carol L. Shields, Patrick De Potter, Larry A. Donoso, Jerry A. Shields, Linda A. Cannizzaro

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

We analyzed cytogenetic abnormalities in 10 cases of primary uveal melanoma. Clonal chromosomal abnormalities were present in nine cases. Chromosome 6 was most commonly affected (seven cases) and included gain of material from 6 and/or loss of material from 6q. Trisomy of chromosome 8 or gain in material from 8q, mostly in the form of an i(8q) resulting in three to five copies of the 8q segment was seen in six cases. Monosomy of chromosome 3 and rearrangements of chromosome 9 were less frequent and were altered in three cases each. Clinical, histopathologic, and cytogenetic abnormalities are correlated.

Original language	English (US)
Pages (from-to)	109-115
Number of pages	7
Journal	Cancer Genetics and Cytogenetics
Volume	72
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(94)90125-2
State	Published - Feb 1994
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/0165-4608(94)90125-2

Cite this

@article{535fb593d81c4b44a6ad617756476b55,

title = "Cytogenetic findings in primary uveal melanoma",

abstract = "We analyzed cytogenetic abnormalities in 10 cases of primary uveal melanoma. Clonal chromosomal abnormalities were present in nine cases. Chromosome 6 was most commonly affected (seven cases) and included gain of material from 6 and/or loss of material from 6q. Trisomy of chromosome 8 or gain in material from 8q, mostly in the form of an i(8q) resulting in three to five copies of the 8q segment was seen in six cases. Monosomy of chromosome 3 and rearrangements of chromosome 9 were less frequent and were altered in three cases each. Clinical, histopathologic, and cytogenetic abnormalities are correlated.",

author = "Singh, {Arun D.} and Leslie Boghosian-Sell and Wary, {Kishore K.} and Shields, {Carol L.} and {De Potter}, Patrick and Donoso, {Larry A.} and Shields, {Jerry A.} and Cannizzaro, {Linda A.}",

note = "Funding Information: This investigation was supported by the Eye Tumor Research Foundation, Philadelphia, PA, and the Macula Foundation, New York, NY.",

year = "1994",

month = feb,

doi = "10.1016/0165-4608(94)90125-2",

language = "English (US)",

volume = "72",

pages = "109--115",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Cytogenetic findings in primary uveal melanoma

AU - Singh, Arun D.

AU - Boghosian-Sell, Leslie

AU - Wary, Kishore K.

AU - Shields, Carol L.

AU - De Potter, Patrick

AU - Donoso, Larry A.

AU - Shields, Jerry A.

AU - Cannizzaro, Linda A.

N1 - Funding Information: This investigation was supported by the Eye Tumor Research Foundation, Philadelphia, PA, and the Macula Foundation, New York, NY.

PY - 1994/2

Y1 - 1994/2

N2 - We analyzed cytogenetic abnormalities in 10 cases of primary uveal melanoma. Clonal chromosomal abnormalities were present in nine cases. Chromosome 6 was most commonly affected (seven cases) and included gain of material from 6 and/or loss of material from 6q. Trisomy of chromosome 8 or gain in material from 8q, mostly in the form of an i(8q) resulting in three to five copies of the 8q segment was seen in six cases. Monosomy of chromosome 3 and rearrangements of chromosome 9 were less frequent and were altered in three cases each. Clinical, histopathologic, and cytogenetic abnormalities are correlated.

AB - We analyzed cytogenetic abnormalities in 10 cases of primary uveal melanoma. Clonal chromosomal abnormalities were present in nine cases. Chromosome 6 was most commonly affected (seven cases) and included gain of material from 6 and/or loss of material from 6q. Trisomy of chromosome 8 or gain in material from 8q, mostly in the form of an i(8q) resulting in three to five copies of the 8q segment was seen in six cases. Monosomy of chromosome 3 and rearrangements of chromosome 9 were less frequent and were altered in three cases each. Clinical, histopathologic, and cytogenetic abnormalities are correlated.

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DO - 10.1016/0165-4608(94)90125-2

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SN - 0165-4608

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JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Cytogenetic findings in primary uveal melanoma

Abstract

ASJC Scopus subject areas

UN SDGs

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