Interet de la ciclosporine dans le traitement des recidives de nephrose apres transplantation renale

Translated title of the contribution: Cyclosporin therapy in recurrent nephrotic syndrome after transplantation

B. Ranchin, M. F. Gagnadoux, M. Broyer, A. Lehnert, A. Juresco, N. Cherif, D. Jan, D. Droz, M. C. Gubler, P. Niaudet

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

From May 1992 to December 1994, 14 children with end stage renal failure secondary to steroid-resistant idiopathic nephrotic syndrome received a cadaver kidney graft. Immediate recurrence of the nephrotic syndrome occurred in four patients. In the four patients, a complete remission was observed shortly after the start of intravenous cyclosporin; two children received in addition methylprednisolone pulses for secondary rejection. Two children were still protein-free 9 and 15 months after transplantation. In the third patient, proteinuria relapsed after 9 months of complete remission and persisted in spite of the reintroduction of intravenous cyclosporin. The fourth graft was lost at 3,5 month from irreversible rejection. The creatinine clearance of the 3 functioning grafts was respectively: 73, 76 and 92 ml/mn/1,73m2 16, 10 and 15 months after transplantation. Intravenous cyclosporin started shortly after the reccurence, maintaining blood levels between 200 and 300 ng/ml, may induce a remission in recurrent nephrotic syndrome after renal transplantation in childhood.

Translated title of the contributionCyclosporin therapy in recurrent nephrotic syndrome after transplantation
Original languageFrench
Pages (from-to)441-445
Number of pages5
JournalNephrologie
Volume17
Issue number8
StatePublished - Dec 1 1996
Externally publishedYes

Keywords

  • child
  • cyclosporin
  • nephrotic syndrome
  • recurrence
  • transplantation

ASJC Scopus subject areas

  • Nephrology

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  • Cite this

    Ranchin, B., Gagnadoux, M. F., Broyer, M., Lehnert, A., Juresco, A., Cherif, N., Jan, D., Droz, D., Gubler, M. C., & Niaudet, P. (1996). Interet de la ciclosporine dans le traitement des recidives de nephrose apres transplantation renale. Nephrologie, 17(8), 441-445.