CX 3CR1 + CD115 + CD135 + common macrophage/DC precursors and the role of CX 3CR1 in their response to inflammation

Cedric Auffray, Darin K. Fogg, Emilie Narni-Mancinelli, Brigitte Senechal, Celine Trouillet, Noah Saederup, Julia Leemput, Karine Bigot, Laura Campisi, Marc Abitbol, Thierry Molina, Israel Charo, David A. Hume, Ana Cumano, Gregoire Lauvau, Frederic Geissmann

Research output: Contribution to journalArticlepeer-review

290 Scopus citations


CX 3CR1 expression is associated with the commitment of CSF-1R myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R + CX 3CR1 + macrophage/DC precursor (MDP) with other DC precursors and the role of CX 3CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1 + inflammatory monocytes that differentiate into TipDCs during infection. CX 3CR1 deficiency selectively impairs the recruitment of blood Gr1 + monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.

Original languageEnglish (US)
Pages (from-to)595-606
Number of pages12
JournalJournal of Experimental Medicine
Issue number3
StatePublished - Mar 16 2009
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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