TY - JOUR
T1 - CX 3CR1 + CD115 + CD135 + common macrophage/DC precursors and the role of CX 3CR1 in their response to inflammation
AU - Auffray, Cedric
AU - Fogg, Darin K.
AU - Narni-Mancinelli, Emilie
AU - Senechal, Brigitte
AU - Trouillet, Celine
AU - Saederup, Noah
AU - Leemput, Julia
AU - Bigot, Karine
AU - Campisi, Laura
AU - Abitbol, Marc
AU - Molina, Thierry
AU - Charo, Israel
AU - Hume, David A.
AU - Cumano, Ana
AU - Lauvau, Gregoire
AU - Geissmann, Frederic
PY - 2009/3/16
Y1 - 2009/3/16
N2 - CX 3CR1 expression is associated with the commitment of CSF-1R myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R + CX 3CR1 + macrophage/DC precursor (MDP) with other DC precursors and the role of CX 3CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1 + inflammatory monocytes that differentiate into TipDCs during infection. CX 3CR1 deficiency selectively impairs the recruitment of blood Gr1 + monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.
AB - CX 3CR1 expression is associated with the commitment of CSF-1R myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R + CX 3CR1 + macrophage/DC precursor (MDP) with other DC precursors and the role of CX 3CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1 + inflammatory monocytes that differentiate into TipDCs during infection. CX 3CR1 deficiency selectively impairs the recruitment of blood Gr1 + monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.
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U2 - 10.1084/jem.20081385
DO - 10.1084/jem.20081385
M3 - Article
C2 - 19273628
AN - SCOPUS:63449110370
SN - 0022-1007
VL - 206
SP - 595
EP - 606
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 3
ER -