Currently available antitussives

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cough is among the most common complaints for which patients seek medical attention. Acute cough, usually due to a viral upper respiratory tract infection, generates a huge expenditure on prescription and over-the-counter cough and cold preparations worldwide. Most of these agents, however, have not been shown to be more effective than placebo in adequately performed clinical trials. The goal of management in chronic cough is treatment of its underlying cause. However, certain situations will necessitate cough suppressant therapy for symptomatic relief. Unfortunately, currently available antitussives, such as the opioids, are not consistently effective, or achieve therapeutic effect at the expense of unpleasant or intolerable side effects. Safer and more effective cough suppressants are desperately needed. Potential novel antitussives will need to be evaluated in properly formulated clinical trials, measuring relevant subjective and objective end points in appropriate subject populations.

Original languageEnglish (US)
Pages (from-to)148-151
Number of pages4
JournalPulmonary Pharmacology and Therapeutics
Volume22
Issue number2
DOIs
StatePublished - Apr 2009

Fingerprint

Antitussive Agents
Cough
Clinical Trials
Therapeutic Uses
Health Expenditures
Respiratory Tract Infections
Opioid Analgesics
Prescriptions
Placebos
Therapeutics
Population

Keywords

  • Antihistamine
  • Antitussive
  • Baclofen
  • Benzonatate
  • Codeine
  • Common cold
  • Cough
  • Dextromethorphan
  • Guaifenesin
  • Levodropropizine
  • Theobromine

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)
  • Biochemistry, medical

Cite this

Currently available antitussives. / Dicpinigaitis, Peter Vytautas.

In: Pulmonary Pharmacology and Therapeutics, Vol. 22, No. 2, 04.2009, p. 148-151.

Research output: Contribution to journalArticle

@article{df8e87cd381b4253acc6599bcbc0f102,
title = "Currently available antitussives",
abstract = "Cough is among the most common complaints for which patients seek medical attention. Acute cough, usually due to a viral upper respiratory tract infection, generates a huge expenditure on prescription and over-the-counter cough and cold preparations worldwide. Most of these agents, however, have not been shown to be more effective than placebo in adequately performed clinical trials. The goal of management in chronic cough is treatment of its underlying cause. However, certain situations will necessitate cough suppressant therapy for symptomatic relief. Unfortunately, currently available antitussives, such as the opioids, are not consistently effective, or achieve therapeutic effect at the expense of unpleasant or intolerable side effects. Safer and more effective cough suppressants are desperately needed. Potential novel antitussives will need to be evaluated in properly formulated clinical trials, measuring relevant subjective and objective end points in appropriate subject populations.",
keywords = "Antihistamine, Antitussive, Baclofen, Benzonatate, Codeine, Common cold, Cough, Dextromethorphan, Guaifenesin, Levodropropizine, Theobromine",
author = "Dicpinigaitis, {Peter Vytautas}",
year = "2009",
month = "4",
doi = "10.1016/j.pupt.2008.08.002",
language = "English (US)",
volume = "22",
pages = "148--151",
journal = "Pulmonary Pharmacology and Therapeutics",
issn = "1094-5539",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Currently available antitussives

AU - Dicpinigaitis, Peter Vytautas

PY - 2009/4

Y1 - 2009/4

N2 - Cough is among the most common complaints for which patients seek medical attention. Acute cough, usually due to a viral upper respiratory tract infection, generates a huge expenditure on prescription and over-the-counter cough and cold preparations worldwide. Most of these agents, however, have not been shown to be more effective than placebo in adequately performed clinical trials. The goal of management in chronic cough is treatment of its underlying cause. However, certain situations will necessitate cough suppressant therapy for symptomatic relief. Unfortunately, currently available antitussives, such as the opioids, are not consistently effective, or achieve therapeutic effect at the expense of unpleasant or intolerable side effects. Safer and more effective cough suppressants are desperately needed. Potential novel antitussives will need to be evaluated in properly formulated clinical trials, measuring relevant subjective and objective end points in appropriate subject populations.

AB - Cough is among the most common complaints for which patients seek medical attention. Acute cough, usually due to a viral upper respiratory tract infection, generates a huge expenditure on prescription and over-the-counter cough and cold preparations worldwide. Most of these agents, however, have not been shown to be more effective than placebo in adequately performed clinical trials. The goal of management in chronic cough is treatment of its underlying cause. However, certain situations will necessitate cough suppressant therapy for symptomatic relief. Unfortunately, currently available antitussives, such as the opioids, are not consistently effective, or achieve therapeutic effect at the expense of unpleasant or intolerable side effects. Safer and more effective cough suppressants are desperately needed. Potential novel antitussives will need to be evaluated in properly formulated clinical trials, measuring relevant subjective and objective end points in appropriate subject populations.

KW - Antihistamine

KW - Antitussive

KW - Baclofen

KW - Benzonatate

KW - Codeine

KW - Common cold

KW - Cough

KW - Dextromethorphan

KW - Guaifenesin

KW - Levodropropizine

KW - Theobromine

UR - http://www.scopus.com/inward/record.url?scp=61649093983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61649093983&partnerID=8YFLogxK

U2 - 10.1016/j.pupt.2008.08.002

DO - 10.1016/j.pupt.2008.08.002

M3 - Article

VL - 22

SP - 148

EP - 151

JO - Pulmonary Pharmacology and Therapeutics

JF - Pulmonary Pharmacology and Therapeutics

SN - 1094-5539

IS - 2

ER -