Curcumin suppresses ovalbumin-induced allergic conjunctivitis

So Hyang Chung, Seong Hyun Choi, Jin A. Choi, Roy S. Chuck, Choun Ki Joo

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: Allergic conjunctivitis (AC) from an allergen-driven T helper 2 (Th2) response is characterized by conjunctival eosinophilic infiltration. Because curcumin has shown anti-allergic activity in an asthma and contact dermatitis laboratory models, we examined whether administration of curcumin could affect the severity of AC and modify the immune response to ovalbumin (OVA) allergen in an experimental AC model. Methods: Mice were challenged with two doses of topical OVA via the conjunctival sac after systemic sensitization with OVA in aluminum hydroxide (ALUM). Curcumin was administered 1 h before OVA challenge. Several indicators for allergy such as serum immunoglubulin E (IgE) antibodies production, eosinophil infiltration into the conjunctiva and Th2 cytokine production were evaluated in mice with or without curcumin treatment. Results: Mice challenged with OVA via the conjunctival sac following systemic sensitization with OVA in ALUM had severe AC. Curcumin administration markedly suppressed IgE-mediated and eosinophil-dependent conjunctival inflammation. In addition, mice administered curcumin had less interleukin-4 (IL-4) and interleukin-5 (IL-5) (Th2 type cytokine) production in conjunctiva, spleen, and cervical lymph nodes than mice in the non-curcumin-administered group. OVA challenge resulted in activation of the production of inducible nitric oxide (iNOS), and curcumin treatment inhibited iNOS production in the conjunctiva. Conclusions: We believe our findings are the first to demonstrate that curcumin treatment suppresses allergic conjunctival inflammation in an experimental AC model.

Original languageEnglish (US)
Pages (from-to)1966-1972
Number of pages7
JournalMolecular Vision
Volume18
StatePublished - Jul 18 2012

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Allergic Conjunctivitis
Curcumin
Ovalbumin
Conjunctiva
Aluminum Hydroxide
Lacrimal Apparatus
Eosinophils
Allergens
Cytokines
Inflammation
Anti-Allergic Agents
Contact Dermatitis
Interleukin-5
Interleukin-4
Antibody Formation
Hypersensitivity
Nitric Oxide
Spleen
Asthma
Lymph Nodes

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Chung, S. H., Choi, S. H., Choi, J. A., Chuck, R. S., & Joo, C. K. (2012). Curcumin suppresses ovalbumin-induced allergic conjunctivitis. Molecular Vision, 18, 1966-1972.

Curcumin suppresses ovalbumin-induced allergic conjunctivitis. / Chung, So Hyang; Choi, Seong Hyun; Choi, Jin A.; Chuck, Roy S.; Joo, Choun Ki.

In: Molecular Vision, Vol. 18, 18.07.2012, p. 1966-1972.

Research output: Contribution to journalArticle

Chung, SH, Choi, SH, Choi, JA, Chuck, RS & Joo, CK 2012, 'Curcumin suppresses ovalbumin-induced allergic conjunctivitis', Molecular Vision, vol. 18, pp. 1966-1972.
Chung SH, Choi SH, Choi JA, Chuck RS, Joo CK. Curcumin suppresses ovalbumin-induced allergic conjunctivitis. Molecular Vision. 2012 Jul 18;18:1966-1972.
Chung, So Hyang ; Choi, Seong Hyun ; Choi, Jin A. ; Chuck, Roy S. ; Joo, Choun Ki. / Curcumin suppresses ovalbumin-induced allergic conjunctivitis. In: Molecular Vision. 2012 ; Vol. 18. pp. 1966-1972.
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