Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent

Aimee E. Krausz, Brandon L. Adler, Vitor Cabral, Mahantesh S. Navati, Jessica Doerner, Rabab A. Charafeddine, Dinesh Chandra, Hongying Liang, Leslie Gunther, Alicea Clendaniel, Stacey Harper, Joel M. Friedman, Joshua D. Nosanchuk, Adam J. Friedman

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Burn wounds are often complicated by bacterial infection, contributing to morbidity and mortality. Agents commonly used to treat burn wound infection are limited by toxicity, incomplete microbial coverage, inadequate penetration, and rising resistance. Curcumin is a naturally derived substance with innate antimicrobial and wound healing properties. Acting by multiple mechanisms, curcumin is less likely than current antibiotics to select for resistant bacteria. Curcumin's poor aqueous solubility and rapid degradation profile hinder usage; nanoparticle encapsulation overcomes this pitfall and enables extended topical delivery of curcumin. In this study, we synthesized and characterized curcumin nanoparticles (curc-np), which inhibited in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in dose-dependent fashion, and inhibited MRSA growth and enhanced wound healing in an in vivo murine wound model. Curc-np may represent a novel topical antimicrobial and wound healing adjuvant for infected burn wounds and other cutaneous injuries. From the Clinical Editor: This team of authors created curcumin nanoparticles in an effort to overcome curcumin's endogenously poor aqueous solubility and demonstrated in a murine model its antimicrobial and wound healing properties that also resulted in growth inhibition of MRSA and Pseudomonas aeruginosa.

Original languageEnglish (US)
Pages (from-to)195-206
Number of pages12
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Curcumin
Wound Healing
Nanoparticles
Methicillin
Solubility
Methicillin-Resistant Staphylococcus aureus
Antibiotics
Encapsulation
Wounds and Injuries
Toxicity
Bacteria
Pseudomonas aeruginosa
Growth
Degradation
Wound Infection
Bacterial Infections
Anti-Bacterial Agents
Morbidity
Skin
Mortality

Keywords

  • Antimicrobial
  • Burn wound
  • Curcumin
  • Infection
  • Nanoparticle
  • Wound healing

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

Cite this

Krausz, A. E., Adler, B. L., Cabral, V., Navati, M. S., Doerner, J., Charafeddine, R. A., ... Friedman, A. J. (2015). Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine: Nanotechnology, Biology, and Medicine, 11(1), 195-206. https://doi.org/10.1016/j.nano.2014.09.004

Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. / Krausz, Aimee E.; Adler, Brandon L.; Cabral, Vitor; Navati, Mahantesh S.; Doerner, Jessica; Charafeddine, Rabab A.; Chandra, Dinesh; Liang, Hongying; Gunther, Leslie; Clendaniel, Alicea; Harper, Stacey; Friedman, Joel M.; Nosanchuk, Joshua D.; Friedman, Adam J.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 11, No. 1, 01.01.2015, p. 195-206.

Research output: Contribution to journalArticle

Krausz, AE, Adler, BL, Cabral, V, Navati, MS, Doerner, J, Charafeddine, RA, Chandra, D, Liang, H, Gunther, L, Clendaniel, A, Harper, S, Friedman, JM, Nosanchuk, JD & Friedman, AJ 2015, 'Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 11, no. 1, pp. 195-206. https://doi.org/10.1016/j.nano.2014.09.004
Krausz, Aimee E. ; Adler, Brandon L. ; Cabral, Vitor ; Navati, Mahantesh S. ; Doerner, Jessica ; Charafeddine, Rabab A. ; Chandra, Dinesh ; Liang, Hongying ; Gunther, Leslie ; Clendaniel, Alicea ; Harper, Stacey ; Friedman, Joel M. ; Nosanchuk, Joshua D. ; Friedman, Adam J. / Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2015 ; Vol. 11, No. 1. pp. 195-206.
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