Cryptococcus neoformans infection can elicit protective antibodies in mice

J. Mukherjee, M. D. Scharff, A. Casadevall

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

An IgG1 monoclonal antibody generated from a mouse infected with Cryptococcus neoformans modified the course of intravenous cryptococcal infection in A/J mice by prolonging survival and reducing lung fungal burden, brain mass, and serum polysaccharide levels. The results demonstrate that C. neoformans infection can elicit useful antibodies.

Original languageEnglish (US)
Pages (from-to)888-892
Number of pages5
JournalCanadian Journal of Microbiology
Volume40
Issue number10
DOIs
Publication statusPublished - Jan 1 1994

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Keywords

  • Antibody immunity
  • Cryptococcus neoformans
  • Monoclonal antibody

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Genetics

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