Crohn's disease

Influence of age at diagnosis on site and clinical type of disease

J. M. Polito, B. Childs, E. D. Mellits, Aaron Zev Tokayer, M. L. Harris, T. M. Bayless

Research output: Contribution to journalArticle

312 Citations (Scopus)

Abstract

Background and Aims: Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. The aim of this study was to examine the influences of age at diagnosis of Crohn's disease on disease site, type, and course. Methods: Records of 552 consecutive patients with Crohn's disease were reviewed retrospectively. Results: Younger age at diagnosis (younger than 20 years), compared with an older age (40 years or older), was associated with a greater prevalence of a family history of Crohn's disease (29.9% vs. 13.6%), greater small bowel involvement (88.7% vs. 57.5%), more structuring disease (45.8% vs. 28.8%), and a higher frequency of surgery (70.6% vs. 55.3%). Older age at diagnosis was associated with a greater prevalence of colonic disease (84.8% vs. 71.2%) and the inflammatory subtype (54.5% vs. 34.4%). A conditional logistic regression analysis confirmed an independent effect of age at diagnosis on ileal disease and surgery for intractable disease. Conclusions: In Crohn's disease, early age at diagnosis is associated with more complicated disease and a greater likelihood of having affected relatives. Stratification of Crohn's disease by age at diagnosis provides support for the concept of genetic heterogeneity.

Original languageEnglish (US)
Pages (from-to)580-586
Number of pages7
JournalGastroenterology
Volume111
Issue number3
StatePublished - 1996
Externally publishedYes

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Crohn Disease
Ileal Diseases
Colonic Diseases
Genetic Heterogeneity
Age Distribution
Logistic Models
Regression Analysis
Phenotype

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Polito, J. M., Childs, B., Mellits, E. D., Tokayer, A. Z., Harris, M. L., & Bayless, T. M. (1996). Crohn's disease: Influence of age at diagnosis on site and clinical type of disease. Gastroenterology, 111(3), 580-586.

Crohn's disease : Influence of age at diagnosis on site and clinical type of disease. / Polito, J. M.; Childs, B.; Mellits, E. D.; Tokayer, Aaron Zev; Harris, M. L.; Bayless, T. M.

In: Gastroenterology, Vol. 111, No. 3, 1996, p. 580-586.

Research output: Contribution to journalArticle

Polito, JM, Childs, B, Mellits, ED, Tokayer, AZ, Harris, ML & Bayless, TM 1996, 'Crohn's disease: Influence of age at diagnosis on site and clinical type of disease', Gastroenterology, vol. 111, no. 3, pp. 580-586.
Polito JM, Childs B, Mellits ED, Tokayer AZ, Harris ML, Bayless TM. Crohn's disease: Influence of age at diagnosis on site and clinical type of disease. Gastroenterology. 1996;111(3):580-586.
Polito, J. M. ; Childs, B. ; Mellits, E. D. ; Tokayer, Aaron Zev ; Harris, M. L. ; Bayless, T. M. / Crohn's disease : Influence of age at diagnosis on site and clinical type of disease. In: Gastroenterology. 1996 ; Vol. 111, No. 3. pp. 580-586.
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