TY - JOUR
T1 - 'Crack' cocaine-induced syndrome mimicking sarcoidosis
AU - Dicpinigaitis, Peter V.
AU - Jones, Joan G.
AU - Frymus, Michael M.
AU - Folkert, Vaughn W.
PY - 1999/6
Y1 - 1999/6
N2 - A 39-year-old man with a history of frequent 'crack' cocaine use of several years' duration presented with progressive dyspnea. Evaluation revealed bilateral interstitial pulmonary infiltrates and hilar adenopathy, diffuse pulmonary uptake of gallium, and markedly elevated serum angiotensin- converting enzyme activity. Open lung biopsy revealed interstitial and perivascular collections of histiocytes containing refractile, polarizable material, presumably inhaled along with the cocaine. Paratracheal lymph nodes were enlarged, reactive, and contained similar polarizable material. The well-formed, non-necrotizing granulomata characteristic of sarcoidosis were not present in either tissue specimen. To our knowledge, the association of chronic crack cocaine inhalation with this constellation of clinical findings, typically seen in sarcoidosis, has not previously been described.
AB - A 39-year-old man with a history of frequent 'crack' cocaine use of several years' duration presented with progressive dyspnea. Evaluation revealed bilateral interstitial pulmonary infiltrates and hilar adenopathy, diffuse pulmonary uptake of gallium, and markedly elevated serum angiotensin- converting enzyme activity. Open lung biopsy revealed interstitial and perivascular collections of histiocytes containing refractile, polarizable material, presumably inhaled along with the cocaine. Paratracheal lymph nodes were enlarged, reactive, and contained similar polarizable material. The well-formed, non-necrotizing granulomata characteristic of sarcoidosis were not present in either tissue specimen. To our knowledge, the association of chronic crack cocaine inhalation with this constellation of clinical findings, typically seen in sarcoidosis, has not previously been described.
KW - Angiotensin converting enzyme (ACE)
KW - Crack cocaine
KW - Gallium scan
KW - Lung diseases, interstitial
KW - Sarcoidosis
UR - http://www.scopus.com/inward/record.url?scp=0033498779&partnerID=8YFLogxK
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U2 - 10.1016/S0002-9629(15)40556-7
DO - 10.1016/S0002-9629(15)40556-7
M3 - Article
C2 - 10372843
AN - SCOPUS:0033498779
SN - 0002-9629
VL - 317
SP - 416
EP - 418
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 6
ER -