TY - JOUR
T1 - COVID-19
T2 - Post-lockdown guidelines
AU - Kostoff, Ronald N.
AU - Briggs, Michael B.
AU - Porter, Alan L.
AU - Aschner, Michael
AU - Spandidos, Demetrios A.
AU - Tsatsakis, Aristidis
N1 - Publisher Copyright:
© 2020 Spandidos Publications. All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - To summarize, first, there is no unanimity within the medical community for continuing the severe restrictions on activities of the vast majority of the total population that are mainly applicable to the most vulnerable, very small minority of the total population. Second, repurposed (mainly) antiviral treatments can only be expected to have very limited results in controlling SARS‑C oV‑2 viral load of the most severely impacted, based on trials conducted so far. Third, it is difficult to see how safe COVID‑ 19 vaccines can be developed and fully tested on time scales of one or two years, as proposed presently. Fourth, the only real protection against a future COVID‑ 19 pandemic or any other viral pandemic is the one that was demonstrated to work in the SARS, MERS, COVID‑ 19 and annual influenza pandemics: a healthy immune system capable of neutralizing incoming viruses as nature intended. We need an Operation Warp Speed (currently working to produce a vaccine in a record short time period in the USA) to identify and eliminate those factors that weaken the immune system as thoroughly, comprehensively, and rapidly as possible.
AB - To summarize, first, there is no unanimity within the medical community for continuing the severe restrictions on activities of the vast majority of the total population that are mainly applicable to the most vulnerable, very small minority of the total population. Second, repurposed (mainly) antiviral treatments can only be expected to have very limited results in controlling SARS‑C oV‑2 viral load of the most severely impacted, based on trials conducted so far. Third, it is difficult to see how safe COVID‑ 19 vaccines can be developed and fully tested on time scales of one or two years, as proposed presently. Fourth, the only real protection against a future COVID‑ 19 pandemic or any other viral pandemic is the one that was demonstrated to work in the SARS, MERS, COVID‑ 19 and annual influenza pandemics: a healthy immune system capable of neutralizing incoming viruses as nature intended. We need an Operation Warp Speed (currently working to produce a vaccine in a record short time period in the USA) to identify and eliminate those factors that weaken the immune system as thoroughly, comprehensively, and rapidly as possible.
KW - ARS-cov-2
KW - COVID-19
KW - Coronavirus
KW - Immune system
KW - Lockdown
KW - MERS-cov
KW - Middle east respiratory syndrome
KW - Pandemic
KW - SARS-cov
KW - Severe acute respiratory syndrome
UR - http://www.scopus.com/inward/record.url?scp=85088209450&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088209450&partnerID=8YFLogxK
U2 - 10.3892/ijmm.2020.4640
DO - 10.3892/ijmm.2020.4640
M3 - Review article
C2 - 32626934
AN - SCOPUS:85088209450
SN - 1107-3756
VL - 46
SP - 463
EP - 466
JO - International journal of molecular medicine
JF - International journal of molecular medicine
IS - 2
ER -