Counterregulatory Adaptation to Recurrent Hypoglycemia in Normal Humans

Maris R. Davis, Harry Shamoon

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

We evaluated the effect of antecedent hypoglycemia on glucose counterregulation during hypoglycemia in nondiabetic human subjects. In single hypoglycemia studies, glucose production ([3H]3-glucose) and counterregulatory hormone concentrations were measured (after a 3.5-h baseline period of euglycemia) during 120 min of hypoglycemia (glucose clamped at 3.0 mmol/L). During the final 60 min of hypoglycemia, counterregulation resulted in significant increments in glucose production (12.88 ± 0.83 μmol/kg · min), and plasma glucagon (IRG; 185 ± 22 ng/L), GH (29.3 ± 7.0 μg/L), cortisol (630 ± 100 nmol/L), epinephrine (3.44 ± 0.76 nmol/L), and norepinephrine (2.02 ± 0.21 nmol/L). In the recurrent hypoglycemia experiment, an antecedent period of identical hypoglycemia was induced. Glucose counterregulation during the second of two periods of hypoglycemia (HYPO 2) was then compared to that in single hypoglycemia studies. During HYPO 2, there were decreased responses in Ra (by 32% P < 0.03), GH (by 67% P < 0.05), F (by 41% P < 0.03), and norepinephrine (by 20% P = 0.03) compared to those in the single hypoglycemia study. In contrast, plasma IRG values were similar in the single hypoglycemia studies and HYPO 2, but were reduced relative to those during the first hypoglycemic period of recurrent hypoglycemia (IRG, 263 ± 18 ng/L; P < 0.025 vs. HYPO 2 and P < 0.05 vs. single hypoglycemia). Our results suggest that 1) antecedent hypoglycemia may alter glucose counterregulation during hypoglycemia; and 2) recurrent hypoglycemia may result in alterations in reduction of hepatic glucose production.

Original languageEnglish (US)
Pages (from-to)995-1001
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume73
Issue number5
DOIs
StatePublished - Nov 1991

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Counterregulatory Adaptation to Recurrent Hypoglycemia in Normal Humans'. Together they form a unique fingerprint.

  • Cite this