Cost-effectiveness of rescreening conventionally prepared cervical smears by PAPNET testing

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

OBJECTIVE: This study explored the cost-effectiveness of the use of PAPNET testing-supplemental, neural network-based testing used to increase the accuracy of cervical smear screening practice. STUDY DESIGN: Using a model adapted from one developed under contract front the United States Congress Office of Technology Assessment to evaluate cost-effectiveness of cervical cancer screening in elderly women, the study evaluated U.S. women aged 20-64. The study reviewed various screening intervals and examined the course of follow-up (i.e., repeat abnormal smear vs. immediate colposcopy) to offer a range into which most routine medical practice will fall. RESULTS: Assuming a false negative rate of 25% for low grade squamous intraepithelial lesion (SIL) and 15% for high grade SIL and applying increased sensitivity of 30% from PAPNET, we can expect a cost of $48,474 per life year saved among biennially screened women. For women screened triennially, as recommended by most groups, the cost per life-year saved is $25,185. CONCLUSION: The PAPNET rescreening program is an economical approach to decreasing mortality and morbidity from cervical cancer and compares favorably to other commonly used interventions and diagnostic procedures.

Original languageEnglish (US)
Pages (from-to)1272-1282
Number of pages11
JournalActa Cytologica
Volume40
Issue number6
StatePublished - 1996
Externally publishedYes

Fingerprint

Vaginal Smears
Cost-Benefit Analysis
United States Office of Technology Assessment
Uterine Cervical Neoplasms
Costs and Cost Analysis
Colposcopy
Contracts
Early Detection of Cancer
Morbidity
Mortality
Squamous Intraepithelial Lesions of the Cervix

Keywords

  • cervical smears
  • cervix neoplasms
  • cost effectiveness
  • Markov process
  • neural networks (computer)
  • PAPNET

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

Cite this

Cost-effectiveness of rescreening conventionally prepared cervical smears by PAPNET testing. / Schechter, Clyde B.

In: Acta Cytologica, Vol. 40, No. 6, 1996, p. 1272-1282.

Research output: Contribution to journalArticle

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