Abstract
The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 953-960 |
| Number of pages | 8 |
| Journal | Mini-Reviews in Medicinal Chemistry |
| Volume | 5 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2005 |
| Externally published | Yes |
Keywords
- CRF binding protein (CRFBP)
- CRFBP inhibitor
- Cognitive deficits
- Corticotropin-releasing factor (CRF)
- Urocortin
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Cancer Research
