Correlation between glucose disposal and amino acids levels in hyperthyroidism

Nir Barzilai, E. Karnieli, D. Barzilai, P. Cohen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Insulin is known to decrease plasma levels of both glucose and amino acids. We have designed a study to examine whether in hyperthyroidism, where insulin sensitivity is changed, correlation between glucose disposal and amino acids levels is maintained. We studied 5 normal (N)) and 5 hyperthyroid (HTD) subjects, and measured glucose disposal rate and serum levels of plasma amino acids before and during insulin infusion utilizing the euglycemic hyperinsulinemic clamp technique. Insulin was effective in decreasing the levels of all amino acids in the plasma of all subjects. The mean amino acid decrease in response to insulin infusion rate of 10 mu/kg/min was 35 ± 3% in N and 50 ± 3% in HTD. The half maximally effective dose of insulin on glucose disposal was 43 ± 3 and 69 ± 9 uU/ml in N and HTD respectively (p < 0.05). The half maximally efective dose of insulin on decreasing plasma amino acids was 37 ± 7 and 75 ± 5 uU/ml in N and HTD respectively (p < 0.01). The concentration of insulin giving a half maximal effect on serum amino acids correlated with the half-maximally effective dose on glucose disposal rate (r = 0.72, p < 0.01). The maximal effect on total amino acid levels correlated with maximal glucose disposal (r = 0.76, p < 0.001). Similar results were observed with branched chain amino acids. We conclude that in hyperthyroidism glucose disposal and decrease in amino acids levels are closely correlated as in healthy subjects. This also confirms the association between glucose disposal and amino acids levels in a variety of insulin sensitive and resistant states.

Original languageEnglish (US)
Pages (from-to)382-385
Number of pages4
JournalHormone and Metabolic Research
Volume25
Issue number7
StatePublished - 1993

Fingerprint

Hyperthyroidism
Amino Acids
Glucose
Insulin
Plasmas
Branched Chain Amino Acids
Glucose Clamp Technique
Clamping devices
Serum
Insulin Resistance
Healthy Volunteers

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Correlation between glucose disposal and amino acids levels in hyperthyroidism. / Barzilai, Nir; Karnieli, E.; Barzilai, D.; Cohen, P.

In: Hormone and Metabolic Research, Vol. 25, No. 7, 1993, p. 382-385.

Research output: Contribution to journalArticle

Barzilai, Nir ; Karnieli, E. ; Barzilai, D. ; Cohen, P. / Correlation between glucose disposal and amino acids levels in hyperthyroidism. In: Hormone and Metabolic Research. 1993 ; Vol. 25, No. 7. pp. 382-385.
@article{3d084e738a204c159a55da99c210a20e,
title = "Correlation between glucose disposal and amino acids levels in hyperthyroidism",
abstract = "Insulin is known to decrease plasma levels of both glucose and amino acids. We have designed a study to examine whether in hyperthyroidism, where insulin sensitivity is changed, correlation between glucose disposal and amino acids levels is maintained. We studied 5 normal (N)) and 5 hyperthyroid (HTD) subjects, and measured glucose disposal rate and serum levels of plasma amino acids before and during insulin infusion utilizing the euglycemic hyperinsulinemic clamp technique. Insulin was effective in decreasing the levels of all amino acids in the plasma of all subjects. The mean amino acid decrease in response to insulin infusion rate of 10 mu/kg/min was 35 ± 3{\%} in N and 50 ± 3{\%} in HTD. The half maximally effective dose of insulin on glucose disposal was 43 ± 3 and 69 ± 9 uU/ml in N and HTD respectively (p < 0.05). The half maximally efective dose of insulin on decreasing plasma amino acids was 37 ± 7 and 75 ± 5 uU/ml in N and HTD respectively (p < 0.01). The concentration of insulin giving a half maximal effect on serum amino acids correlated with the half-maximally effective dose on glucose disposal rate (r = 0.72, p < 0.01). The maximal effect on total amino acid levels correlated with maximal glucose disposal (r = 0.76, p < 0.001). Similar results were observed with branched chain amino acids. We conclude that in hyperthyroidism glucose disposal and decrease in amino acids levels are closely correlated as in healthy subjects. This also confirms the association between glucose disposal and amino acids levels in a variety of insulin sensitive and resistant states.",
author = "Nir Barzilai and E. Karnieli and D. Barzilai and P. Cohen",
year = "1993",
language = "English (US)",
volume = "25",
pages = "382--385",
journal = "Hormone and Metabolic Research",
issn = "0018-5043",
publisher = "Georg Thieme Verlag",
number = "7",

}

TY - JOUR

T1 - Correlation between glucose disposal and amino acids levels in hyperthyroidism

AU - Barzilai, Nir

AU - Karnieli, E.

AU - Barzilai, D.

AU - Cohen, P.

PY - 1993

Y1 - 1993

N2 - Insulin is known to decrease plasma levels of both glucose and amino acids. We have designed a study to examine whether in hyperthyroidism, where insulin sensitivity is changed, correlation between glucose disposal and amino acids levels is maintained. We studied 5 normal (N)) and 5 hyperthyroid (HTD) subjects, and measured glucose disposal rate and serum levels of plasma amino acids before and during insulin infusion utilizing the euglycemic hyperinsulinemic clamp technique. Insulin was effective in decreasing the levels of all amino acids in the plasma of all subjects. The mean amino acid decrease in response to insulin infusion rate of 10 mu/kg/min was 35 ± 3% in N and 50 ± 3% in HTD. The half maximally effective dose of insulin on glucose disposal was 43 ± 3 and 69 ± 9 uU/ml in N and HTD respectively (p < 0.05). The half maximally efective dose of insulin on decreasing plasma amino acids was 37 ± 7 and 75 ± 5 uU/ml in N and HTD respectively (p < 0.01). The concentration of insulin giving a half maximal effect on serum amino acids correlated with the half-maximally effective dose on glucose disposal rate (r = 0.72, p < 0.01). The maximal effect on total amino acid levels correlated with maximal glucose disposal (r = 0.76, p < 0.001). Similar results were observed with branched chain amino acids. We conclude that in hyperthyroidism glucose disposal and decrease in amino acids levels are closely correlated as in healthy subjects. This also confirms the association between glucose disposal and amino acids levels in a variety of insulin sensitive and resistant states.

AB - Insulin is known to decrease plasma levels of both glucose and amino acids. We have designed a study to examine whether in hyperthyroidism, where insulin sensitivity is changed, correlation between glucose disposal and amino acids levels is maintained. We studied 5 normal (N)) and 5 hyperthyroid (HTD) subjects, and measured glucose disposal rate and serum levels of plasma amino acids before and during insulin infusion utilizing the euglycemic hyperinsulinemic clamp technique. Insulin was effective in decreasing the levels of all amino acids in the plasma of all subjects. The mean amino acid decrease in response to insulin infusion rate of 10 mu/kg/min was 35 ± 3% in N and 50 ± 3% in HTD. The half maximally effective dose of insulin on glucose disposal was 43 ± 3 and 69 ± 9 uU/ml in N and HTD respectively (p < 0.05). The half maximally efective dose of insulin on decreasing plasma amino acids was 37 ± 7 and 75 ± 5 uU/ml in N and HTD respectively (p < 0.01). The concentration of insulin giving a half maximal effect on serum amino acids correlated with the half-maximally effective dose on glucose disposal rate (r = 0.72, p < 0.01). The maximal effect on total amino acid levels correlated with maximal glucose disposal (r = 0.76, p < 0.001). Similar results were observed with branched chain amino acids. We conclude that in hyperthyroidism glucose disposal and decrease in amino acids levels are closely correlated as in healthy subjects. This also confirms the association between glucose disposal and amino acids levels in a variety of insulin sensitive and resistant states.

UR - http://www.scopus.com/inward/record.url?scp=0027305096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027305096&partnerID=8YFLogxK

M3 - Article

C2 - 8406325

AN - SCOPUS:0027305096

VL - 25

SP - 382

EP - 385

JO - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

SN - 0018-5043

IS - 7

ER -