Coronary bare metal stent implantation in homozygous LDL receptor deficient swine induces a neointimal formation pattern similar to humans

Armando Tellez, Christian G. Krueger, Paul Seifert, Dawn Winsor-Hines, Cristian Piedrahita, Yanping Cheng, Krzysztof Milewski, Michael S. Aboodi, Genghua Yi, Jennifer C. McGregor, Tom Crenshaw, Jess D. Reed, Barbara Huibregtse, Greg L. Kaluza, Juan F. Granada

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Introduction: To date, most of all new developments in stent technologies are tested in normal animals. Although invaluable in the evaluation of device safety, the juvenile domestic swine (DS) do not follow the biological healing response occurring in humans following coronary stent implantation. By using a novel swine breed afflicted with familial hypercholesterolemia (FHS), we aimed to analyse the vascular response occurring following bare metal stent (BMS) implantation by comparing in vivo endovascular imaging and histological data. Methods: A total of 26 swine were included in this study (12 FHS and 14 DS). Sixty eight BMS (FHS = 28 versus DS = 40) were implanted using a 10% overstretch ratio. Imaging evaluation (IVUS and OCT) was conducted in all animals at 30 (n= 14) or 90 (n= 12) days following stent implantation. After imaging, the stented coronary segments were harvested for histological evaluation. Results: At 30 days, the degree of neointimal formation analysed by OCT (%AS = DS 21.9 ± 10% versus FHS 25.4 ± 12%; p= 0.18) and histology (DS 24.6 ± 10% versus FHS 23.58 ± 10%; p= 0.8) was similar between both animal groups. At 90 days, the degree of neointimal formation in the DS group decreased in all analysed variables (-40% in IVUS neointimal volume, -57% in OCT %AS, and -30% in %AS by histology) compared to the progression of neointimal formation observed in the FHS group (+29% in IVUS neointimal volume, +27% in OCT %AS and +43% in %AS by histology). Conclusion: The pattern of neointimal formation following BMS implantation in the FHS follows a progressive course that does not occur in the DS. Therefore, by providing a progressive neointimal biological response to BMS implantation, the FHS could serve as an ideal efficacy model for the validation of drug eluting stent technologies.

Original languageEnglish (US)
Pages (from-to)518-524
Number of pages7
JournalAtherosclerosis
Volume213
Issue number2
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • Animal models of disease
  • Coronary neointimal formation
  • Familial hypercholesterolemic swine
  • Intravascular ultrasound
  • Optical coherence tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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