Contribution of the SuUR gene to the organization of epigenetically repressed regions of Drosophila melanogaster chromosomes

T. D. Kolesnikova; E. N. Andreeva; A. V. Pindiurin; N. G. Anan'ko; S. N. Beliakin; V. V. Shloma; A. A. Iurlova; I. V. Makunin; G. V. Pokholkova; E. I. Volkova; E. A. Zarutskaia; E. B. Kokoza; V. F. Seneshin; E. S. Beliaeva; I. F. Zhimulev

Contribution of the SuUR gene to the organization of epigenetically repressed regions of Drosophila melanogaster chromosomes

T. D. Kolesnikova, E. N. Andreeva, A. V. Pindiurin, N. G. Anan'ko, S. N. Beliakin, V. V. Shloma, A. A. Iurlova, I. V. Makunin, G. V. Pokholkova, E. I. Volkova, E. A. Zarutskaia, E. B. Kokoza, V. F. Seneshin, E. S. Beliaeva, I. F. Zhimulev

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

A significant portion of a eukaryotic genome is silent (epigenetically repressed). In Drosophila melanogaster, this portion includes mainly regions of pericentric and intercalary heterochromatin and euchromatin regions subject to position-effect variegation. Detailed study of the organization of intercalary heterochromatin regions of Drosophila melanogaster polytene chromosomes started from the discovery of the SuUR gene (Suppressor of UnderReplication). The ability of the SuUR mutation to suppress underreplication in intercalary heterochromatin regions was used for molecular tagging of these regions. We showed that underreplicated intercalary heterochromatin regions contained silent unique genes and retained the features of late replication and transcriptionally inactive chromatin state in various cell types. Over 50% of these regions contain unique genes clustered on the base of coordinated expression. The origin of clusters and putative mechanisms of their gene expression are discussed. Data on the SuUR gene, its expression, and effect on polytene chromosome structure and replication are summarized.

Original language	English (US)
Pages (from-to)	1013-1028
Number of pages	16
Journal	Genetika
Volume	42
Issue number	8
State	Published - Aug 2006
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Kolesnikova, T. D., Andreeva, E. N., Pindiurin, A. V., Anan'ko, N. G., Beliakin, S. N., Shloma, V. V., Iurlova, A. A., Makunin, I. V., Pokholkova, G. V., Volkova, E. I., Zarutskaia, E. A., Kokoza, E. B., Seneshin, V. F., Beliaeva, E. S., & Zhimulev, I. F. (2006). Contribution of the SuUR gene to the organization of epigenetically repressed regions of Drosophila melanogaster chromosomes. Genetika, 42(8), 1013-1028.

Kolesnikova, TD, Andreeva, EN, Pindiurin, AV, Anan'ko, NG, Beliakin, SN, Shloma, VV, Iurlova, AA, Makunin, IV, Pokholkova, GV, Volkova, EI, Zarutskaia, EA, Kokoza, EB, Seneshin, VF, Beliaeva, ES & Zhimulev, IF 2006, 'Contribution of the SuUR gene to the organization of epigenetically repressed regions of Drosophila melanogaster chromosomes', Genetika, vol. 42, no. 8, pp. 1013-1028.

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title = "Contribution of the SuUR gene to the organization of epigenetically repressed regions of Drosophila melanogaster chromosomes",

abstract = "A significant portion of a eukaryotic genome is silent (epigenetically repressed). In Drosophila melanogaster, this portion includes mainly regions of pericentric and intercalary heterochromatin and euchromatin regions subject to position-effect variegation. Detailed study of the organization of intercalary heterochromatin regions of Drosophila melanogaster polytene chromosomes started from the discovery of the SuUR gene (Suppressor of UnderReplication). The ability of the SuUR mutation to suppress underreplication in intercalary heterochromatin regions was used for molecular tagging of these regions. We showed that underreplicated intercalary heterochromatin regions contained silent unique genes and retained the features of late replication and transcriptionally inactive chromatin state in various cell types. Over 50% of these regions contain unique genes clustered on the base of coordinated expression. The origin of clusters and putative mechanisms of their gene expression are discussed. Data on the SuUR gene, its expression, and effect on polytene chromosome structure and replication are summarized.",

author = "Kolesnikova, {T. D.} and Andreeva, {E. N.} and Pindiurin, {A. V.} and Anan'ko, {N. G.} and Beliakin, {S. N.} and Shloma, {V. V.} and Iurlova, {A. A.} and Makunin, {I. V.} and Pokholkova, {G. V.} and Volkova, {E. I.} and Zarutskaia, {E. A.} and Kokoza, {E. B.} and Seneshin, {V. F.} and Beliaeva, {E. S.} and Zhimulev, {I. F.}",

year = "2006",

month = aug,

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AU - Andreeva, E. N.

AU - Pindiurin, A. V.

AU - Anan'ko, N. G.

AU - Beliakin, S. N.

AU - Shloma, V. V.

AU - Iurlova, A. A.

AU - Makunin, I. V.

AU - Pokholkova, G. V.

AU - Volkova, E. I.

AU - Zarutskaia, E. A.

AU - Kokoza, E. B.

AU - Seneshin, V. F.

AU - Beliaeva, E. S.

AU - Zhimulev, I. F.

PY - 2006/8

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N2 - A significant portion of a eukaryotic genome is silent (epigenetically repressed). In Drosophila melanogaster, this portion includes mainly regions of pericentric and intercalary heterochromatin and euchromatin regions subject to position-effect variegation. Detailed study of the organization of intercalary heterochromatin regions of Drosophila melanogaster polytene chromosomes started from the discovery of the SuUR gene (Suppressor of UnderReplication). The ability of the SuUR mutation to suppress underreplication in intercalary heterochromatin regions was used for molecular tagging of these regions. We showed that underreplicated intercalary heterochromatin regions contained silent unique genes and retained the features of late replication and transcriptionally inactive chromatin state in various cell types. Over 50% of these regions contain unique genes clustered on the base of coordinated expression. The origin of clusters and putative mechanisms of their gene expression are discussed. Data on the SuUR gene, its expression, and effect on polytene chromosome structure and replication are summarized.

AB - A significant portion of a eukaryotic genome is silent (epigenetically repressed). In Drosophila melanogaster, this portion includes mainly regions of pericentric and intercalary heterochromatin and euchromatin regions subject to position-effect variegation. Detailed study of the organization of intercalary heterochromatin regions of Drosophila melanogaster polytene chromosomes started from the discovery of the SuUR gene (Suppressor of UnderReplication). The ability of the SuUR mutation to suppress underreplication in intercalary heterochromatin regions was used for molecular tagging of these regions. We showed that underreplicated intercalary heterochromatin regions contained silent unique genes and retained the features of late replication and transcriptionally inactive chromatin state in various cell types. Over 50% of these regions contain unique genes clustered on the base of coordinated expression. The origin of clusters and putative mechanisms of their gene expression are discussed. Data on the SuUR gene, its expression, and effect on polytene chromosome structure and replication are summarized.

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M3 - Review article

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Contribution of the SuUR gene to the organization of epigenetically repressed regions of Drosophila melanogaster chromosomes

Abstract

ASJC Scopus subject areas

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