Contemporary radiation countermeasures

Vivek N. Patel, Seema Gupta, Mohammed M. Shareef, Mansoor M. Ahmed

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Radiation countermeasures have been investigated for decades, but the search for ideal protective agents for use prior to or after irradiation still continues. This review focuses on agents that have demonstrated as potential as in vivo countermeasure agents and may subsequently be effectively used in human beings. Such agents are categorised as radioprotectors, radiation mitigators, or therapeutic agents dependening upon their time of administration. These protective or mitigating agents are designed to reduce inadvertent damage to normal tissue caused by radiation. These interventions function via various mechanisms of action ranging from modulating signalling pathways to inhibiting cell death, cytokines, and growth factor. Many agents demonstrated promising results in murine models and are being tested in human beings. Amifostine, and curcumin have shown radioprotection, while genistein, palifermin, and halofuginone have been shown to alleviate the side effects in patients undergoing radiotherapy. Though these compounds show some promise as radiation countermeasure agents, there are several associated limitations and the search for perfect agents still continues.

Original languageEnglish (US)
Pages (from-to)138-145
Number of pages8
JournalDefence Science Journal
Volume61
Issue number2
DOIs
StatePublished - Mar 2011

Keywords

  • Radiation counter measures
  • Radiation mitigators
  • Radioprotectors
  • Radiotherapy
  • Therapeutic agents

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Biomedical Engineering
  • Mechanical Engineering
  • Physics and Astronomy(all)
  • Computer Science Applications
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Contemporary radiation countermeasures'. Together they form a unique fingerprint.

  • Cite this

    Patel, V. N., Gupta, S., Shareef, M. M., & Ahmed, M. M. (2011). Contemporary radiation countermeasures. Defence Science Journal, 61(2), 138-145. https://doi.org/10.14429/dsj.61.834