Connectomics, the Final Frontier

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

How the synaptic connections in the nervous system are genetically encoded and formed during development remains an unsolved problem. The known connectivity of the nervous system of the nematode C. elegans provides an opportunity to search for the genes involved. The circuits for male mating behavior form a complex neural network that would seem to require a large family of molecular cell labels for pre- and postsynaptic cell recognition. It is suggested that a combinatorial code of neural cell adhesion proteins specifying the network of connections may be discovered by comparing the expression patterns of candidate genes with the pattern of connections.

Original languageEnglish (US)
JournalCurrent Topics in Developmental Biology
DOIs
StateAccepted/In press - 2016

Keywords

  • C. elegans
  • Combinatorial code
  • Nervous system
  • Nervous system development
  • Neural cell adhesion protein
  • Neural network
  • Synapse
  • Synaptic connectivity

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Connectomics, the Final Frontier'. Together they form a unique fingerprint.

  • Cite this