Confirming glycemic status in the diabetes prevention program: Implications for diagnosing diabetes in high risk adults

C. A. Christophi, H. E. Resnick, R. E. Ratner, M. Temprosa, S. Fowler, W. C. Knowler, Harry Shamoon, E. Barrett-Connor, S. E. Kahn

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aims: To examine the ability of fasting plasma glucose (FPG) and/or 2-h glucose to confirm diabetes and to determine the proportion of participants with HbA1c ≥ 6.5%. Methods: Diabetes confirmation rates were calculated after a single elevated FPG and/or 2-h glucose on an oral glucose tolerance test (OGTT) using a confirmatory OGTT performed within 6 weeks. Results: 772 (24%) participants had elevated FPG or 2-h glucose on an OGTT that triggered a confirmation visit. There were 101 triggers on FPG alone, 574 on 2-h glucose alone, and 97 on both. Only 47% of participants who triggered had confirmed diabetes. While the confirmation rate for FPG was higher than that for 2-h glucose, the larger number of 2-h glucose triggers resulted in 87% of confirmed cases triggering on 2-h glucose. Confirmation rates increased to 75% among persons with FPG ≥ 126 mg/dl and HbA1c ≥ 6.5%. Conclusions: Only half of the persons with elevated FPG and IGT were subsequently confirmed to have diabetes. At current diagnostic levels, more persons trigger on 2-h glucose than on FPG, but fewer of these persons have their diagnoses confirmed. In individuals with FPG ≥ 126 mg/dl and HbA1c ≥ 6.5%, the confirmation rate was increased.

Original languageEnglish (US)
Pages (from-to)150-157
Number of pages8
JournalJournal of Diabetes and its Complications
Volume27
Issue number2
DOIs
StatePublished - Mar 2013

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Glucose
Fasting
Glucose Tolerance Test
Aptitude

Keywords

  • Diabetes mellitus
  • Epidemiology
  • Screening

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Confirming glycemic status in the diabetes prevention program : Implications for diagnosing diabetes in high risk adults. / Christophi, C. A.; Resnick, H. E.; Ratner, R. E.; Temprosa, M.; Fowler, S.; Knowler, W. C.; Shamoon, Harry; Barrett-Connor, E.; Kahn, S. E.

In: Journal of Diabetes and its Complications, Vol. 27, No. 2, 03.2013, p. 150-157.

Research output: Contribution to journalArticle

Christophi, CA, Resnick, HE, Ratner, RE, Temprosa, M, Fowler, S, Knowler, WC, Shamoon, H, Barrett-Connor, E & Kahn, SE 2013, 'Confirming glycemic status in the diabetes prevention program: Implications for diagnosing diabetes in high risk adults', Journal of Diabetes and its Complications, vol. 27, no. 2, pp. 150-157. https://doi.org/10.1016/j.jdiacomp.2012.09.012
Christophi, C. A. ; Resnick, H. E. ; Ratner, R. E. ; Temprosa, M. ; Fowler, S. ; Knowler, W. C. ; Shamoon, Harry ; Barrett-Connor, E. ; Kahn, S. E. / Confirming glycemic status in the diabetes prevention program : Implications for diagnosing diabetes in high risk adults. In: Journal of Diabetes and its Complications. 2013 ; Vol. 27, No. 2. pp. 150-157.
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abstract = "Aims: To examine the ability of fasting plasma glucose (FPG) and/or 2-h glucose to confirm diabetes and to determine the proportion of participants with HbA1c ≥ 6.5{\%}. Methods: Diabetes confirmation rates were calculated after a single elevated FPG and/or 2-h glucose on an oral glucose tolerance test (OGTT) using a confirmatory OGTT performed within 6 weeks. Results: 772 (24{\%}) participants had elevated FPG or 2-h glucose on an OGTT that triggered a confirmation visit. There were 101 triggers on FPG alone, 574 on 2-h glucose alone, and 97 on both. Only 47{\%} of participants who triggered had confirmed diabetes. While the confirmation rate for FPG was higher than that for 2-h glucose, the larger number of 2-h glucose triggers resulted in 87{\%} of confirmed cases triggering on 2-h glucose. Confirmation rates increased to 75{\%} among persons with FPG ≥ 126 mg/dl and HbA1c ≥ 6.5{\%}. Conclusions: Only half of the persons with elevated FPG and IGT were subsequently confirmed to have diabetes. At current diagnostic levels, more persons trigger on 2-h glucose than on FPG, but fewer of these persons have their diagnoses confirmed. In individuals with FPG ≥ 126 mg/dl and HbA1c ≥ 6.5{\%}, the confirmation rate was increased.",
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