Computer and mobile technology interventions to promote medication adherence and disease management in people with thalassemia

Sherif M. Badawy, Kerry A. Morrone, Alexis Thompson, Tonya M. Palermo

Research output: Contribution to journalReview article

Abstract

Background Thalassemia syndromes are inherited hemoglobin disorders that result when the synthesis of normal hemoglobin is lacking or significantly reduced. For people with thalassemia, long-term red blood cell transfusion remains the mainstay of therapy, which may lead to iron overload causing severe complications and damage in different body organs. Long-term iron chelation therapy is essential for people with thalassemia to minimize the ongoing iron-loading process. In addition, suboptimal adherence can increase adverse events associated with iron overload and result in increased morbidity, mortality, healthcare utilization and cost of care. Objectives To identify and assess the effects of computer and mobile technology interventions designed to facilitate medication adherence and disease management in individuals with thalassemia, including:-evaluating the effects of using computer and mobile technology interventions for medication adherence and disease management on health and behavioral outcomes;-identifying and assessing the effects of computer and mobile technology interventions specific to different age groups (children, adolescents and adults) and type of modality (e.g. cell phone, the Internet). Search methods We searched CENTRAL (the Cochrane Library), MEDLINE, Embase, CINAHL, PsycINFO, ProQuest Dissertations & Theses Global, Psychology and Behavioral Sciences Collection, Web of Science Science & Social Sciences Conference Proceedings Indexes, IEEE Xplore and ongoing trial databases (22 February 2018). We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group’s Haemoglobinopathies Trials Register (20 June 2019). We also searched for unpublished work in the abstract book of nine major conferences in the related field.

Original languageEnglish (US)
Article numberCD012900
JournalCochrane Database of Systematic Reviews
Volume2019
Issue number6
DOIs
StatePublished - Jun 28 2019

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Thalassemia
Medication Adherence
Disease Management
Technology
Iron Overload
Hemoglobins
Iron
Chelation Therapy
Behavioral Sciences
Hemoglobinopathies
Erythrocyte Transfusion
Inborn Genetic Diseases
Cell Phones
Social Sciences
Cystic Fibrosis
MEDLINE
Health Care Costs
Internet
Libraries
Age Groups

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Computer and mobile technology interventions to promote medication adherence and disease management in people with thalassemia. / Badawy, Sherif M.; Morrone, Kerry A.; Thompson, Alexis; Palermo, Tonya M.

In: Cochrane Database of Systematic Reviews, Vol. 2019, No. 6, CD012900, 28.06.2019.

Research output: Contribution to journalReview article

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N2 - Background Thalassemia syndromes are inherited hemoglobin disorders that result when the synthesis of normal hemoglobin is lacking or significantly reduced. For people with thalassemia, long-term red blood cell transfusion remains the mainstay of therapy, which may lead to iron overload causing severe complications and damage in different body organs. Long-term iron chelation therapy is essential for people with thalassemia to minimize the ongoing iron-loading process. In addition, suboptimal adherence can increase adverse events associated with iron overload and result in increased morbidity, mortality, healthcare utilization and cost of care. Objectives To identify and assess the effects of computer and mobile technology interventions designed to facilitate medication adherence and disease management in individuals with thalassemia, including:-evaluating the effects of using computer and mobile technology interventions for medication adherence and disease management on health and behavioral outcomes;-identifying and assessing the effects of computer and mobile technology interventions specific to different age groups (children, adolescents and adults) and type of modality (e.g. cell phone, the Internet). Search methods We searched CENTRAL (the Cochrane Library), MEDLINE, Embase, CINAHL, PsycINFO, ProQuest Dissertations & Theses Global, Psychology and Behavioral Sciences Collection, Web of Science Science & Social Sciences Conference Proceedings Indexes, IEEE Xplore and ongoing trial databases (22 February 2018). We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group’s Haemoglobinopathies Trials Register (20 June 2019). We also searched for unpublished work in the abstract book of nine major conferences in the related field.

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