Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects

Steven C. Persak, Sanghun Sin, Raanan Arens, David M. Wootton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Three-dimensional (3D) analysis of the deforming airway during tidal breathing has not been performed in children with obstructive sleep apnea. We used volume-gated magnetic resonance images to segment, surface, and volume mesh the airway of one child with obstructive sleep apnea syndrome (OSAS) and one control. A computational fluid dynamics (CFD) study was performed on each airway at flow rates corresponding to 10 time points of a respiratory cycle extracted from flow data averaged over 12 consecutive breathing cycles. 3D CFD analysis showed the minimum inspiratory pressure for the OSAS subject was -250.76 Pa and - 124.24 Pa for the control. Gated MRI images depicted an overall 47% decrease in airway volume over the inspiratory cycle for the OSAS subject while the control experienced no collapse. Pressure distribution corrected for nasal resistance and turbulence kinetic energy data suggest airway collapsibility in the OSAS is a function of pharyngeal resistance and fluid and tissue mechanics rather than entirely nasal resistance.

Original languageEnglish (US)
Title of host publicationProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
DOIs
StatePublished - 2010
Externally publishedYes
Event36th Annual Northeast Bioengineering Conference, NEBEC 2010 - New York, NY, United States
Duration: Mar 26 2010Mar 28 2010

Other

Other36th Annual Northeast Bioengineering Conference, NEBEC 2010
CountryUnited States
CityNew York, NY
Period3/26/103/28/10

Fingerprint

Magnetic resonance imaging
Computational fluid dynamics
Magnetic resonance
Kinetic energy
Pressure distribution
Dynamic analysis
Mechanics
Turbulence
Flow rate
Sleep
Tissue
Fluids

ASJC Scopus subject areas

  • Bioengineering

Cite this

Persak, S. C., Sin, S., Arens, R., & Wootton, D. M. (2010). Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects. In Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010 [5458124] https://doi.org/10.1109/NEBC.2010.5458124

Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects. / Persak, Steven C.; Sin, Sanghun; Arens, Raanan; Wootton, David M.

Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010. 2010. 5458124.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Persak, SC, Sin, S, Arens, R & Wootton, DM 2010, Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects. in Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010., 5458124, 36th Annual Northeast Bioengineering Conference, NEBEC 2010, New York, NY, United States, 3/26/10. https://doi.org/10.1109/NEBC.2010.5458124
Persak SC, Sin S, Arens R, Wootton DM. Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects. In Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010. 2010. 5458124 https://doi.org/10.1109/NEBC.2010.5458124
Persak, Steven C. ; Sin, Sanghun ; Arens, Raanan ; Wootton, David M. / Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects. Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010. 2010.
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