Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects

Steven C. Persak; Sanghun Sin; Raanan Arens; David M. Wootton

doi:10.1109/NEBC.2010.5458124

Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects

Steven C. Persak, Sanghun Sin, Raanan Arens, David M. Wootton

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Three-dimensional (3D) analysis of the deforming airway during tidal breathing has not been performed in children with obstructive sleep apnea. We used volume-gated magnetic resonance images to segment, surface, and volume mesh the airway of one child with obstructive sleep apnea syndrome (OSAS) and one control. A computational fluid dynamics (CFD) study was performed on each airway at flow rates corresponding to 10 time points of a respiratory cycle extracted from flow data averaged over 12 consecutive breathing cycles. 3D CFD analysis showed the minimum inspiratory pressure for the OSAS subject was -250.76 Pa and - 124.24 Pa for the control. Gated MRI images depicted an overall 47% decrease in airway volume over the inspiratory cycle for the OSAS subject while the control experienced no collapse. Pressure distribution corrected for nasal resistance and turbulence kinetic energy data suggest airway collapsibility in the OSAS is a function of pharyngeal resistance and fluid and tissue mechanics rather than entirely nasal resistance.

Original language	English (US)
Title of host publication	Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
DOIs	https://doi.org/10.1109/NEBC.2010.5458124
State	Published - Jun 8 2010
Externally published	Yes
Event	36th Annual Northeast Bioengineering Conference, NEBEC 2010 - New York, NY, United States Duration: Mar 26 2010 → Mar 28 2010

Publication series

Name	Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010

Other

Other	36th Annual Northeast Bioengineering Conference, NEBEC 2010
Country/Territory	United States
City	New York, NY
Period	3/26/10 → 3/28/10

ASJC Scopus subject areas

Bioengineering

Access to Document

10.1109/NEBC.2010.5458124

Cite this

Persak, S. C., Sin, S., Arens, R., & Wootton, D. M. (2010). Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects. In Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010 [5458124] (Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010). https://doi.org/10.1109/NEBC.2010.5458124

Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects. / Persak, Steven C.; Sin, Sanghun ; Arens, Raanan et al.
Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010. 2010. 5458124 (Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Persak, SC, Sin, S , Arens, R & Wootton, DM 2010, Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects. in Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010., 5458124, Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010, 36th Annual Northeast Bioengineering Conference, NEBEC 2010, New York, NY, United States, 3/26/10. https://doi.org/10.1109/NEBC.2010.5458124

Persak SC, Sin S , Arens R, Wootton DM. Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects. In Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010. 2010. 5458124. (Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010). doi: 10.1109/NEBC.2010.5458124

Persak, Steven C. ; Sin, Sanghun ; Arens, Raanan et al. / Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects. Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010. 2010. (Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010).

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title = "Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects",

abstract = "Three-dimensional (3D) analysis of the deforming airway during tidal breathing has not been performed in children with obstructive sleep apnea. We used volume-gated magnetic resonance images to segment, surface, and volume mesh the airway of one child with obstructive sleep apnea syndrome (OSAS) and one control. A computational fluid dynamics (CFD) study was performed on each airway at flow rates corresponding to 10 time points of a respiratory cycle extracted from flow data averaged over 12 consecutive breathing cycles. 3D CFD analysis showed the minimum inspiratory pressure for the OSAS subject was -250.76 Pa and - 124.24 Pa for the control. Gated MRI images depicted an overall 47% decrease in airway volume over the inspiratory cycle for the OSAS subject while the control experienced no collapse. Pressure distribution corrected for nasal resistance and turbulence kinetic energy data suggest airway collapsibility in the OSAS is a function of pharyngeal resistance and fluid and tissue mechanics rather than entirely nasal resistance.",

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AB - Three-dimensional (3D) analysis of the deforming airway during tidal breathing has not been performed in children with obstructive sleep apnea. We used volume-gated magnetic resonance images to segment, surface, and volume mesh the airway of one child with obstructive sleep apnea syndrome (OSAS) and one control. A computational fluid dynamics (CFD) study was performed on each airway at flow rates corresponding to 10 time points of a respiratory cycle extracted from flow data averaged over 12 consecutive breathing cycles. 3D CFD analysis showed the minimum inspiratory pressure for the OSAS subject was -250.76 Pa and - 124.24 Pa for the control. Gated MRI images depicted an overall 47% decrease in airway volume over the inspiratory cycle for the OSAS subject while the control experienced no collapse. Pressure distribution corrected for nasal resistance and turbulence kinetic energy data suggest airway collapsibility in the OSAS is a function of pharyngeal resistance and fluid and tissue mechanics rather than entirely nasal resistance.

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Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects

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