Complex methylmercury-cysteine alters mercury accumulation in different tissues of mice

Daniel Henrique Roos, Robson Luiz Puntel, Thiago Henrique Lugokenski, Rafael Porto Ineu, Denise Bohrer, Marilise E. Burger, Jeferson L. Franco, Marcelo Farina, Michael Aschner, João Batista T Rocha, Nilda B. De Vargas Barbosa

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Methylmercury (MeHg) can cause deleterious effects in vertebrate tissues, particularly in the central nervous system. MeHg interacts with sulfhydryl groups from low and high molecular weight thiols in the blood, which can facilitate MeHg uptake into different tissues. The purpose of this study was to examine the effect of MeHg-Cysteine (MeHg-Cys) complex administration on Hg-uptake in cerebral areas (cortex and cerebellum), liver and kidney of adult mice. Animals were divided into four groups: control (1 mLkg distilled water), MeHg (2 mgkg), Cys (2 mgkg) and MeHg-Cys complex (0.8 molar ratio). Mice received one intraperitoneal injection per day for 60 consecutive days. Treatment with MeHg significantly increased mercury concentrations in all tissues analysed when compared with the control group. The accumulation of mercury in brain and in liver was further increased in animals that received MeHg-Cys complex when compared with the MeHg alone group. However, renal Hg decreased in MeHg-Cys treated mice, when compared with the group treated only with MeHg. In summary, the transport of MeHg-Cys complex was tissue-specific, and we observed an increase in its uptake by liver and brain as well as a decrease in kidney.

Original languageEnglish (US)
Pages (from-to)789-792
Number of pages4
JournalBasic and Clinical Pharmacology and Toxicology
Volume107
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Mercury
Liver
Tissue
Kidney
Brain
Animals
Control Groups
Neurology
Intraperitoneal Injections
Sulfhydryl Compounds
Cerebral Cortex
Cerebellum
Cysteine
Vertebrates
Blood
Central Nervous System
Molecular Weight
Molecular weight
methylmercury cysteine
Water

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Pharmacology

Cite this

Roos, D. H., Puntel, R. L., Lugokenski, T. H., Ineu, R. P., Bohrer, D., Burger, M. E., ... De Vargas Barbosa, N. B. (2010). Complex methylmercury-cysteine alters mercury accumulation in different tissues of mice. Basic and Clinical Pharmacology and Toxicology, 107(4), 789-792. https://doi.org/10.1111/j.1742-7843.2010.00577.x

Complex methylmercury-cysteine alters mercury accumulation in different tissues of mice. / Roos, Daniel Henrique; Puntel, Robson Luiz; Lugokenski, Thiago Henrique; Ineu, Rafael Porto; Bohrer, Denise; Burger, Marilise E.; Franco, Jeferson L.; Farina, Marcelo; Aschner, Michael; Rocha, João Batista T; De Vargas Barbosa, Nilda B.

In: Basic and Clinical Pharmacology and Toxicology, Vol. 107, No. 4, 2010, p. 789-792.

Research output: Contribution to journalArticle

Roos, DH, Puntel, RL, Lugokenski, TH, Ineu, RP, Bohrer, D, Burger, ME, Franco, JL, Farina, M, Aschner, M, Rocha, JBT & De Vargas Barbosa, NB 2010, 'Complex methylmercury-cysteine alters mercury accumulation in different tissues of mice', Basic and Clinical Pharmacology and Toxicology, vol. 107, no. 4, pp. 789-792. https://doi.org/10.1111/j.1742-7843.2010.00577.x
Roos, Daniel Henrique ; Puntel, Robson Luiz ; Lugokenski, Thiago Henrique ; Ineu, Rafael Porto ; Bohrer, Denise ; Burger, Marilise E. ; Franco, Jeferson L. ; Farina, Marcelo ; Aschner, Michael ; Rocha, João Batista T ; De Vargas Barbosa, Nilda B. / Complex methylmercury-cysteine alters mercury accumulation in different tissues of mice. In: Basic and Clinical Pharmacology and Toxicology. 2010 ; Vol. 107, No. 4. pp. 789-792.
@article{72c53b6e628242958da95ea7582853ba,
title = "Complex methylmercury-cysteine alters mercury accumulation in different tissues of mice",
abstract = "Methylmercury (MeHg) can cause deleterious effects in vertebrate tissues, particularly in the central nervous system. MeHg interacts with sulfhydryl groups from low and high molecular weight thiols in the blood, which can facilitate MeHg uptake into different tissues. The purpose of this study was to examine the effect of MeHg-Cysteine (MeHg-Cys) complex administration on Hg-uptake in cerebral areas (cortex and cerebellum), liver and kidney of adult mice. Animals were divided into four groups: control (1 mLkg distilled water), MeHg (2 mgkg), Cys (2 mgkg) and MeHg-Cys complex (0.8 molar ratio). Mice received one intraperitoneal injection per day for 60 consecutive days. Treatment with MeHg significantly increased mercury concentrations in all tissues analysed when compared with the control group. The accumulation of mercury in brain and in liver was further increased in animals that received MeHg-Cys complex when compared with the MeHg alone group. However, renal Hg decreased in MeHg-Cys treated mice, when compared with the group treated only with MeHg. In summary, the transport of MeHg-Cys complex was tissue-specific, and we observed an increase in its uptake by liver and brain as well as a decrease in kidney.",
author = "Roos, {Daniel Henrique} and Puntel, {Robson Luiz} and Lugokenski, {Thiago Henrique} and Ineu, {Rafael Porto} and Denise Bohrer and Burger, {Marilise E.} and Franco, {Jeferson L.} and Marcelo Farina and Michael Aschner and Rocha, {Jo{\~a}o Batista T} and {De Vargas Barbosa}, {Nilda B.}",
year = "2010",
doi = "10.1111/j.1742-7843.2010.00577.x",
language = "English (US)",
volume = "107",
pages = "789--792",
journal = "Basic and Clinical Pharmacology and Toxicology",
issn = "1742-7835",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Complex methylmercury-cysteine alters mercury accumulation in different tissues of mice

AU - Roos, Daniel Henrique

AU - Puntel, Robson Luiz

AU - Lugokenski, Thiago Henrique

AU - Ineu, Rafael Porto

AU - Bohrer, Denise

AU - Burger, Marilise E.

AU - Franco, Jeferson L.

AU - Farina, Marcelo

AU - Aschner, Michael

AU - Rocha, João Batista T

AU - De Vargas Barbosa, Nilda B.

PY - 2010

Y1 - 2010

N2 - Methylmercury (MeHg) can cause deleterious effects in vertebrate tissues, particularly in the central nervous system. MeHg interacts with sulfhydryl groups from low and high molecular weight thiols in the blood, which can facilitate MeHg uptake into different tissues. The purpose of this study was to examine the effect of MeHg-Cysteine (MeHg-Cys) complex administration on Hg-uptake in cerebral areas (cortex and cerebellum), liver and kidney of adult mice. Animals were divided into four groups: control (1 mLkg distilled water), MeHg (2 mgkg), Cys (2 mgkg) and MeHg-Cys complex (0.8 molar ratio). Mice received one intraperitoneal injection per day for 60 consecutive days. Treatment with MeHg significantly increased mercury concentrations in all tissues analysed when compared with the control group. The accumulation of mercury in brain and in liver was further increased in animals that received MeHg-Cys complex when compared with the MeHg alone group. However, renal Hg decreased in MeHg-Cys treated mice, when compared with the group treated only with MeHg. In summary, the transport of MeHg-Cys complex was tissue-specific, and we observed an increase in its uptake by liver and brain as well as a decrease in kidney.

AB - Methylmercury (MeHg) can cause deleterious effects in vertebrate tissues, particularly in the central nervous system. MeHg interacts with sulfhydryl groups from low and high molecular weight thiols in the blood, which can facilitate MeHg uptake into different tissues. The purpose of this study was to examine the effect of MeHg-Cysteine (MeHg-Cys) complex administration on Hg-uptake in cerebral areas (cortex and cerebellum), liver and kidney of adult mice. Animals were divided into four groups: control (1 mLkg distilled water), MeHg (2 mgkg), Cys (2 mgkg) and MeHg-Cys complex (0.8 molar ratio). Mice received one intraperitoneal injection per day for 60 consecutive days. Treatment with MeHg significantly increased mercury concentrations in all tissues analysed when compared with the control group. The accumulation of mercury in brain and in liver was further increased in animals that received MeHg-Cys complex when compared with the MeHg alone group. However, renal Hg decreased in MeHg-Cys treated mice, when compared with the group treated only with MeHg. In summary, the transport of MeHg-Cys complex was tissue-specific, and we observed an increase in its uptake by liver and brain as well as a decrease in kidney.

UR - http://www.scopus.com/inward/record.url?scp=84984577794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984577794&partnerID=8YFLogxK

U2 - 10.1111/j.1742-7843.2010.00577.x

DO - 10.1111/j.1742-7843.2010.00577.x

M3 - Article

VL - 107

SP - 789

EP - 792

JO - Basic and Clinical Pharmacology and Toxicology

JF - Basic and Clinical Pharmacology and Toxicology

SN - 1742-7835

IS - 4

ER -