TY - JOUR
T1 - Comparison of the pyrogenicity, limulus activity, mitogenicity and complement reactivity of several bacterial endotoxins and related compounds
AU - Elin, R. J.
AU - Sandberg, A. L.
AU - Rosenstreich, D. L.
PY - 1976
Y1 - 1976
N2 - The correlation of mitogenicity, complement activation, pyrogenicity and Limulus amebocyte lysate (LAL) gelation induced by 17 bacterial endotoxins (LPS), modified endotoxins, related compounds, and other B cell mitogens was examined. With the use of these compounds, a significant correlation was found between pyrogenicity and mitogenicity (r= 0.85, p < 0.0005), pyrogenicity and LAL reactivity (r= 0.84, p < 0.0005), and mitogenicity and LAL reactivity (r=0.72, p < 0.0025). In contrast, complement activation by these compounds did not correlate with mitogenicity, pyrogenicity or LAL reactivity (r = 0.09, p > 0.4; r = -0.17, p > 0.3; r = 0.17, p > 0.3, respectively). These results suggest that a specific chemical configuration may induce mitogenicity, pyrogenicity and LAL reactivity which differs from that responsible for complement activation.
AB - The correlation of mitogenicity, complement activation, pyrogenicity and Limulus amebocyte lysate (LAL) gelation induced by 17 bacterial endotoxins (LPS), modified endotoxins, related compounds, and other B cell mitogens was examined. With the use of these compounds, a significant correlation was found between pyrogenicity and mitogenicity (r= 0.85, p < 0.0005), pyrogenicity and LAL reactivity (r= 0.84, p < 0.0005), and mitogenicity and LAL reactivity (r=0.72, p < 0.0025). In contrast, complement activation by these compounds did not correlate with mitogenicity, pyrogenicity or LAL reactivity (r = 0.09, p > 0.4; r = -0.17, p > 0.3; r = 0.17, p > 0.3, respectively). These results suggest that a specific chemical configuration may induce mitogenicity, pyrogenicity and LAL reactivity which differs from that responsible for complement activation.
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M3 - Article
C2 - 789771
AN - SCOPUS:0017133007
SN - 0022-1767
VL - 117
SP - 1238
EP - 1242
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -