The correlation of mitogenicity, complement activation, pyrogenicity and Limulus amebocyte lysate (LAL) gelation induced by 17 bacterial endotoxins (LPS), modified endotoxins, related compounds, and other B cell mitogens was examined. With the use of these compounds, a significant correlation was found between pyrogenicity and mitogenicity (r= 0.85, p < 0.0005), pyrogenicity and LAL reactivity (r= 0.84, p < 0.0005), and mitogenicity and LAL reactivity (r=0.72, p < 0.0025). In contrast, complement activation by these compounds did not correlate with mitogenicity, pyrogenicity or LAL reactivity (r = 0.09, p > 0.4; r = -0.17, p > 0.3; r = 0.17, p > 0.3, respectively). These results suggest that a specific chemical configuration may induce mitogenicity, pyrogenicity and LAL reactivity which differs from that responsible for complement activation.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Immunology|
|State||Published - Dec 1 1976|
ASJC Scopus subject areas
- Immunology and Allergy