Comparison of the pyrogenicity, limulus activity, mitogenicity and complement reactivity of several bacterial endotoxins and related compounds

R. J. Elin, A. L. Sandberg, D. L. Rosenstreich

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Abstract

The correlation of mitogenicity, complement activation, pyrogenicity and Limulus amebocyte lysate (LAL) gelation induced by 17 bacterial endotoxins (LPS), modified endotoxins, related compounds, and other B cell mitogens was examined. With the use of these compounds, a significant correlation was found between pyrogenicity and mitogenicity (r= 0.85, p < 0.0005), pyrogenicity and LAL reactivity (r= 0.84, p < 0.0005), and mitogenicity and LAL reactivity (r=0.72, p < 0.0025). In contrast, complement activation by these compounds did not correlate with mitogenicity, pyrogenicity or LAL reactivity (r = 0.09, p > 0.4; r = -0.17, p > 0.3; r = 0.17, p > 0.3, respectively). These results suggest that a specific chemical configuration may induce mitogenicity, pyrogenicity and LAL reactivity which differs from that responsible for complement activation.

Original languageEnglish (US)
Pages (from-to)1238-1242
Number of pages5
JournalJournal of Immunology
Volume117
Issue number4
StatePublished - Dec 1 1976
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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