TY - JOUR
T1 - Comparison of the plasma levels of apolipoproteins B and A-1, and other risk factors in men and women with premature coronary artery disease
AU - Kwiterovich, Peter O.
AU - Coresh, Josef
AU - Smith, Hazel H.
AU - Bachorik, Paul S.
AU - Derby, Carol A.
AU - Pearson, Thomas A.
N1 - Funding Information:
From the Lipid-Research Atherosclerosis Unit, Departments of Pediatrics, Medicine, and Epidemiology, the Johns Hopkins Medical Institutions, Baltimore, Maryland. This study was supported by Grant HL 31497 from the National Institutes of Health, Bethesda, Maryland. Manuscript received September 9, 1991; revised manuscript received and accepted December 11,199 1.
PY - 1992/4/15
Y1 - 1992/4/15
N2 - The predictors of premature coronary atherosclerosis were examined in 203 patients (99 men aged ≤50 years, and 104 women aged ≤60 years) undergoing elective diagnostic coronary arteriography. Age, cigarette smoking, hypertension, obesity, diabetes, positive family history of premature coronary artery disease (CAD), and plasma levels of total cholesterol, triglyceride, lipoproteins (i.e., very low, intermediate-, low-, and high-density [HDL] lipoproteins and their subfractions [HDL2 and HDL3], and lipoprotein [a]) and apolipoproteins (apoA-1, apoA-2 and apoB, respectively) were examined using univariate analyses and multivariate logistic regression. In men, age (p < 0.05), smoking (p < 0.05), and plasma triglyceride (p < 0.02) and apoA-1 (p < 0.05) levels were independently associated with CAD. In women, smoking (p < 0.001) and plasma apoB levels (p < 0.04) were the strongest variables independently associated with CAD. It is concluded that the "nontraditional" risk factors (plasma apoA-1 and apoB levels) are better predictors of premature CAD than are plasma lipoproteins and that smoking is the strongest of the traditional nonlipid risk factors.
AB - The predictors of premature coronary atherosclerosis were examined in 203 patients (99 men aged ≤50 years, and 104 women aged ≤60 years) undergoing elective diagnostic coronary arteriography. Age, cigarette smoking, hypertension, obesity, diabetes, positive family history of premature coronary artery disease (CAD), and plasma levels of total cholesterol, triglyceride, lipoproteins (i.e., very low, intermediate-, low-, and high-density [HDL] lipoproteins and their subfractions [HDL2 and HDL3], and lipoprotein [a]) and apolipoproteins (apoA-1, apoA-2 and apoB, respectively) were examined using univariate analyses and multivariate logistic regression. In men, age (p < 0.05), smoking (p < 0.05), and plasma triglyceride (p < 0.02) and apoA-1 (p < 0.05) levels were independently associated with CAD. In women, smoking (p < 0.001) and plasma apoB levels (p < 0.04) were the strongest variables independently associated with CAD. It is concluded that the "nontraditional" risk factors (plasma apoA-1 and apoB levels) are better predictors of premature CAD than are plasma lipoproteins and that smoking is the strongest of the traditional nonlipid risk factors.
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U2 - 10.1016/0002-9149(92)90856-T
DO - 10.1016/0002-9149(92)90856-T
M3 - Article
C2 - 1561971
AN - SCOPUS:0027076078
SN - 0002-9149
VL - 69
SP - 1015
EP - 1021
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 12
ER -
