Abstract
The predictors of premature coronary atherosclerosis were examined in 203 patients (99 men aged ≤50 years, and 104 women aged ≤60 years) undergoing elective diagnostic coronary arteriography. Age, cigarette smoking, hypertension, obesity, diabetes, positive family history of premature coronary artery disease (CAD), and plasma levels of total cholesterol, triglyceride, lipoproteins (i.e., very low, intermediate-, low-, and high-density [HDL] lipoproteins and their subfractions [HDL2 and HDL3], and lipoprotein [a]) and apolipoproteins (apoA-1, apoA-2 and apoB, respectively) were examined using univariate analyses and multivariate logistic regression. In men, age (p < 0.05), smoking (p < 0.05), and plasma triglyceride (p < 0.02) and apoA-1 (p < 0.05) levels were independently associated with CAD. In women, smoking (p < 0.001) and plasma apoB levels (p < 0.04) were the strongest variables independently associated with CAD. It is concluded that the "nontraditional" risk factors (plasma apoA-1 and apoB levels) are better predictors of premature CAD than are plasma lipoproteins and that smoking is the strongest of the traditional nonlipid risk factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1015-1021 |
| Number of pages | 7 |
| Journal | The American Journal of Cardiology |
| Volume | 69 |
| Issue number | 12 |
| DOIs | |
| State | Published - Apr 15 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Comparison of the plasma levels of apolipoproteins B and A-1, and other risk factors in men and women with premature coronary artery disease. / Kwiterovich, Peter O.; Coresh, Josef; Smith, Hazel H.; Bachorik, Paul S.; Derby, Carol A.; Pearson, Thomas A.
In: The American Journal of Cardiology, Vol. 69, No. 12, 15.04.1992, p. 1015-1021.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Comparison of the plasma levels of apolipoproteins B and A-1, and other risk factors in men and women with premature coronary artery disease
AU - Kwiterovich, Peter O.
AU - Coresh, Josef
AU - Smith, Hazel H.
AU - Bachorik, Paul S.
AU - Derby, Carol A.
AU - Pearson, Thomas A.
PY - 1992/4/15
Y1 - 1992/4/15
N2 - The predictors of premature coronary atherosclerosis were examined in 203 patients (99 men aged ≤50 years, and 104 women aged ≤60 years) undergoing elective diagnostic coronary arteriography. Age, cigarette smoking, hypertension, obesity, diabetes, positive family history of premature coronary artery disease (CAD), and plasma levels of total cholesterol, triglyceride, lipoproteins (i.e., very low, intermediate-, low-, and high-density [HDL] lipoproteins and their subfractions [HDL2 and HDL3], and lipoprotein [a]) and apolipoproteins (apoA-1, apoA-2 and apoB, respectively) were examined using univariate analyses and multivariate logistic regression. In men, age (p < 0.05), smoking (p < 0.05), and plasma triglyceride (p < 0.02) and apoA-1 (p < 0.05) levels were independently associated with CAD. In women, smoking (p < 0.001) and plasma apoB levels (p < 0.04) were the strongest variables independently associated with CAD. It is concluded that the "nontraditional" risk factors (plasma apoA-1 and apoB levels) are better predictors of premature CAD than are plasma lipoproteins and that smoking is the strongest of the traditional nonlipid risk factors.
AB - The predictors of premature coronary atherosclerosis were examined in 203 patients (99 men aged ≤50 years, and 104 women aged ≤60 years) undergoing elective diagnostic coronary arteriography. Age, cigarette smoking, hypertension, obesity, diabetes, positive family history of premature coronary artery disease (CAD), and plasma levels of total cholesterol, triglyceride, lipoproteins (i.e., very low, intermediate-, low-, and high-density [HDL] lipoproteins and their subfractions [HDL2 and HDL3], and lipoprotein [a]) and apolipoproteins (apoA-1, apoA-2 and apoB, respectively) were examined using univariate analyses and multivariate logistic regression. In men, age (p < 0.05), smoking (p < 0.05), and plasma triglyceride (p < 0.02) and apoA-1 (p < 0.05) levels were independently associated with CAD. In women, smoking (p < 0.001) and plasma apoB levels (p < 0.04) were the strongest variables independently associated with CAD. It is concluded that the "nontraditional" risk factors (plasma apoA-1 and apoB levels) are better predictors of premature CAD than are plasma lipoproteins and that smoking is the strongest of the traditional nonlipid risk factors.
UR - http://www.scopus.com/inward/record.url?scp=0027076078&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027076078&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(92)90856-T
DO - 10.1016/0002-9149(92)90856-T
M3 - Article
VL - 69
SP - 1015
EP - 1021
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 12
ER -