Comparison of obstetric outcomes in twin pregnancies after in vitro fertilization, ovarian stimulation and spontaneous conception

S. Putterman, R. Figueroa, D. Garry, D. Maulik

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To compare the outcomes of liveborn twin gestations conceived after in vitro fertilization (IVF) or ovarian stimulation with spontaneously conceived twin pregnancies. Methods: A review of all twin gestations delivered at Winthrop-University Hospital from 1 January 1999 to 31 December 2000. Women who underwent fetal reduction or had a demise of one twin were excluded. Maternal demographics, antepartum complications, mode of delivery and perinatal outcome were compared. Results: Sixty pregnancies were conceived after IVF, 34 were conceived by ovarian stimulation and 101 were spontaneously conceived. Women in the IVF group were older (p < 0.001), were more often 35 years or older (p < 0.001) and primiparous (p = 0.005). More women in the ovarian stimulation group had a poor obstetric history (p = 0.04). Spontaneous gestations had a higher incidence of monochorionic placentations (p = 0.002). There were no differences in gestational age at delivery, antepartum complications, or mode of delivery. There were fewer low-birth-weight neonates in the IVF group (odds ratio 0.59, 95% confidence interval 0.35-0.98; p = 0.03) than in the spontaneous group, but the difference disappeared when only the dichorionic pregnancies were compared. Other neonatal outcomes studied were the same among groups. Conclusion: Twin gestations conceived following IVF and ovarian stimulation appear to have similar outcomes to spontaneously conceived twin gestations.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume14
Issue number4
StatePublished - Oct 2003
Externally publishedYes

Fingerprint

Twin Pregnancy
Ovulation Induction
Fertilization in Vitro
Obstetrics
Pregnancy
Multifetal Pregnancy Reduction
Placentation
Low Birth Weight Infant
Gestational Age
History
Odds Ratio
Mothers
Demography
Newborn Infant
Confidence Intervals
Incidence

Keywords

  • Assisted reproduction
  • In vitro fertilization
  • Perinatal outcome
  • Prematurity
  • Twin gestation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Comparison of obstetric outcomes in twin pregnancies after in vitro fertilization, ovarian stimulation and spontaneous conception. / Putterman, S.; Figueroa, R.; Garry, D.; Maulik, D.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 14, No. 4, 10.2003, p. 237-240.

Research output: Contribution to journalArticle

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