Comparison of methods of evaluating nephrotoxicity of cis-platinum

Brian R. Jones, Ravi B. Bhalla, Jiri Mladek, Ronald N. Kaleya, Richard J. Gralla, Nancy W. Alcock, Morton K. Schwartz, Charles W. Young, Marcus M. Reidenberg

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

The urinary, excretion of leucine aminopeptidase (LAP), N-acetyl-β-glucosaminidase (NAG), and β2-microglobulin was measured in 12 cancer patients receiving cis-platinum to evaluate the sensitivity, of these indices for renal tubular damage. NAG and LAP excretion rose markedly in all patients, and β2-microglobulin rose in 11. Seven of the 9 patients who had received cis-platinum 6 wk before the study had prestudy dose elevations of one or more of these indices. We conclude that these urinary proteins are sensitive indicators of proximal renal tubular injury and may provide greater sensitivity for comparison of the nephrotoxic potential of future platinum analogs or for assessing the efficacy, of regimens designed to protect the kidney from platinum nephrotoxicity than other measurements. The persistence of high excretion values for these indices 6 wk after a dose demonstrates the persistent renal injury, by cis-platinum.

Original languageEnglish (US)
Pages (from-to)557-562
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume27
Issue number4
DOIs
StatePublished - Apr 1980

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Jones, B. R., Bhalla, R. B., Mladek, J., Kaleya, R. N., Gralla, R. J., Alcock, N. W., Schwartz, M. K., Young, C. W., & Reidenberg, M. M. (1980). Comparison of methods of evaluating nephrotoxicity of cis-platinum. Clinical Pharmacology and Therapeutics, 27(4), 557-562. https://doi.org/10.1038/clpt.1980.79