Comparison of hematological alterations and markers of B-cell activation in workers exposed to benzene, formaldehyde and trichloroethylene

Bryan A. Bassig, Luoping Zhang, Roel Vermeulen, Xiaojiang Tang, Guilan Li, Wei Hu, Weihong Guo, Mark P. Purdue, Songnian Yin, Stephen M. Rappaport, Min Shen, Zhiying Ji, Chuangyi Qiu, Yichen Ge, Howard D. Hosgood, Boris Reiss, Banghua Wu, Yuxuan Xie, Laiyu Li, Fei YueLaura E Beane Freeman, Aaron Blair, Richard B. Hayes, Hanlin Huang, Martyn T. Smith, Nathaniel Rothman, Qing Lan

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21 Scopus citations

Abstract

Benzene, formaldehyde (FA) and trichloroethylene (TCE) are ubiquitous chemicals in workplaces and the general environment. Benzene is an established myeloid leukemogen and probable lymphomagen. FA is classified as a myeloid leukemogen but has not been associated with non-Hodgkin lymphoma (NHL), whereas TCE has been associated with NHL but not myeloid leukemia. Epidemiologic associations between FA and myeloid leukemia, and between benzene, TCE and NHL are, however, still debated. Previously, we showed that these chemicals are associated with hematotoxicity in cross-sectional studies of factory workers in China, which included extensive personal monitoring and biological sample collection. Here, we compare and contrast patterns of hematotoxicity, monosomy 7 in myeloid progenitor cells (MPCs), and B-cell activation biomarkers across these studies to further evaluate possible mechanisms of action and consistency of effects with observed hematologic cancer risks. Workers exposed to benzene or FA, but not TCE, showed declines in cell types derived from MPCs, including granulocytes and platelets. Alterations in lymphoid cell types, including B cells and CD4+ T cells, and B-cell activation markers were apparent in workers exposed to benzene or TCE. Given that alterations in myeloid and lymphoid cell types are associated with hematological malignancies, our data provide biologic insight into the epidemiological evidence linking benzene and FA exposure with myeloid leukemia risk, and TCE and benzene exposure with NHL risk.

Original languageEnglish (US)
Pages (from-to)692-700
Number of pages9
JournalCarcinogenesis
Volume37
Issue number7
DOIs
StatePublished - Jul 1 2016

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ASJC Scopus subject areas

  • Cancer Research

Cite this

Bassig, B. A., Zhang, L., Vermeulen, R., Tang, X., Li, G., Hu, W., Guo, W., Purdue, M. P., Yin, S., Rappaport, S. M., Shen, M., Ji, Z., Qiu, C., Ge, Y., Hosgood, H. D., Reiss, B., Wu, B., Xie, Y., Li, L., ... Lan, Q. (2016). Comparison of hematological alterations and markers of B-cell activation in workers exposed to benzene, formaldehyde and trichloroethylene. Carcinogenesis, 37(7), 692-700. https://doi.org/10.1093/carcin/bgw053