Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin

Edward K. Chapnick, Jeremy D. Gradon, Barry Kreiswirth, Larry I. Lutwick, Benjamin C. Schaffer, Thomas D. Schiano, Michael H. Levi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost (Infect Control Hosp Epidemiol 1996;17:178-180).

Original languageEnglish (US)
Pages (from-to)178-180
Number of pages3
JournalInfection Control and Hospital Epidemiology
Volume17
Issue number3
StatePublished - Mar 1996

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Mupirocin
Bacitracin
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Cost Control

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)

Cite this

Chapnick, E. K., Gradon, J. D., Kreiswirth, B., Lutwick, L. I., Schaffer, B. C., Schiano, T. D., & Levi, M. H. (1996). Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin. Infection Control and Hospital Epidemiology, 17(3), 178-180.

Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin. / Chapnick, Edward K.; Gradon, Jeremy D.; Kreiswirth, Barry; Lutwick, Larry I.; Schaffer, Benjamin C.; Schiano, Thomas D.; Levi, Michael H.

In: Infection Control and Hospital Epidemiology, Vol. 17, No. 3, 03.1996, p. 178-180.

Research output: Contribution to journalArticle

Chapnick, EK, Gradon, JD, Kreiswirth, B, Lutwick, LI, Schaffer, BC, Schiano, TD & Levi, MH 1996, 'Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin', Infection Control and Hospital Epidemiology, vol. 17, no. 3, pp. 178-180.
Chapnick EK, Gradon JD, Kreiswirth B, Lutwick LI, Schaffer BC, Schiano TD et al. Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin. Infection Control and Hospital Epidemiology. 1996 Mar;17(3):178-180.
Chapnick, Edward K. ; Gradon, Jeremy D. ; Kreiswirth, Barry ; Lutwick, Larry I. ; Schaffer, Benjamin C. ; Schiano, Thomas D. ; Levi, Michael H. / Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin. In: Infection Control and Hospital Epidemiology. 1996 ; Vol. 17, No. 3. pp. 178-180.
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