Comparative genetics of longevity and cancer: Insights from long-lived rodents

Vera Gorbunova, Andrei Seluanov, Zhengdong Zhang, Vadim N. Gladyshev, Jan Vijg

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.

Original languageEnglish (US)
Pages (from-to)531-540
Number of pages10
JournalNature Reviews Genetics
Volume15
Issue number8
DOIs
StatePublished - 2014

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Mole Rats
Rodentia
Neoplasms
Mammals
Genome

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

Cite this

Comparative genetics of longevity and cancer : Insights from long-lived rodents. / Gorbunova, Vera; Seluanov, Andrei; Zhang, Zhengdong; Gladyshev, Vadim N.; Vijg, Jan.

In: Nature Reviews Genetics, Vol. 15, No. 8, 2014, p. 531-540.

Research output: Contribution to journalArticle

Gorbunova, Vera ; Seluanov, Andrei ; Zhang, Zhengdong ; Gladyshev, Vadim N. ; Vijg, Jan. / Comparative genetics of longevity and cancer : Insights from long-lived rodents. In: Nature Reviews Genetics. 2014 ; Vol. 15, No. 8. pp. 531-540.
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