Comparative genetics of longevity and cancer: Insights from long-lived rodents

Vera Gorbunova, Andrei Seluanov, Zhengdong Zhang, Vadim N. Gladyshev, Jan Vijg

Research output: Contribution to journalReview article

102 Scopus citations

Abstract

Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.

Original languageEnglish (US)
Pages (from-to)531-540
Number of pages10
JournalNature Reviews Genetics
Volume15
Issue number8
DOIs
StatePublished - Aug 2014

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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