Comparative evaluation of F-18 FDOPA, F-18 FDG, and F-18 FLT-PET/CT for metabolic imaging of low grade gliomas

Madhavi Tripathi, Rajnish Sharma, Maria D'Souza, Abhinav Jaimini, Puja Panwar, Raunak Varshney, Anupama Datta, Nitin Kumar, Gunjan Garg, Dinesh Singh, Rajesh K. Grover, Anil K. Mishra, Anupam Mondal

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

INTRODUCTION:: We undertook this prospective study to compare amino acid metabolism, glucose metabolism, and proliferation in primary and recurrent low grade gliomas using positron emission tomography (PET)/computed tomography with F-18 FDOPA, F-18 FDG, and F-18 FLTMethods: Fifteen patients with newly diagnosed or previously treated low grade gliomas (WHO grade I or II) were subjected to F-18-FDOPA, F-18 FDG, and F-18 FLT PET/computed tomography studies on consecutive daysThis included 2 patients in remission as control subjectsUptake of all the 3 tracers were analyzed visually and quantified using standardized uptake values and tumor to normal (T/N) ratiosThe accuracy of all the 3 PET tracers in the detection of newly diagnosed and recurrent low grade gliomas was comparedResults: F-18 FDOPA was positive in all cases of primary and recurrent low grade gliomas and negative in the patients in remissionTumor was visualized on F-18 FDG in 7 of 13 cases, F-18-FLT was positive in 4 of 13 casesAverage tumor standardized uptake values max for F-18 FDOPA (5.75 ± 4.9) and F-18 FLT (1.8 ± 0.91) was lower than that of F-18 FDG (8.5 ± 4.4)T/N ratios for F-18-FDOPA (2.3 ± 0.51) and F-18 FLT (1.8 ± 0.91) were higher than F-18 FDG (1.03 ± 0.64) providing good image contrast for tumor detection in positive casesCONCLUSION:: F-18 FDOPA scan is superior to both F-18 FLT and F-18 FDG for visualization of primary and recurrent low grade gliomasF-18-FLT should not be considered for evaluation of recurrent low grade gliomas.

Original languageEnglish (US)
Pages (from-to)878-883
Number of pages6
JournalClinical nuclear medicine
Volume34
Issue number12
DOIs
StatePublished - Dec 2009
Externally publishedYes

Keywords

  • F-18 FDG
  • F-18 FLT
  • F-18-FDOPA
  • Low grade gliomas
  • PET/CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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