Comparative analysis of systemic immunological parameters in ulcerative colitis and idiopathic proctitis: Effects of sulfasalazine in vivo and in vitro

Arye Rubinstein, K. M. Das, J. Melamed, R. A. Murphy

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Abstract

Comparative analysis of the systemic immunity revealed similarities between ulcerative colitis and idiopathic proctitis. In the active stage of both diseases, circulating complement receptor positive cells were increased whereas T-cell percentages and lymphocyte functions were decreased. In severe forms of ulcerative colitis and idiopathic proctitis circulating EAC-phagocytosing esterase positive cells, indicative of activated monocytes, were demonstrated. Successful treatment with salicylazosulfapyridine (SASP) reversed these immunological changes. Incubation of SASP and its metabolites with leucocytes from patients and control subjects, in concentration similar to those demonstrated in sera from patients treated with SASP, did not alter the immunological changes.

Original languageEnglish (US)
Pages (from-to)217-224
Number of pages8
JournalClinical and Experimental Immunology
Volume33
Issue number2
StatePublished - 1978

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Proctitis
Sulfasalazine
Ulcerative Colitis
T-Lymphocytes
Complement Receptors
Esterases
Phagocytosis
Monocytes
Immunity
Leukocytes
Serum
In Vitro Techniques
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

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AB - Comparative analysis of the systemic immunity revealed similarities between ulcerative colitis and idiopathic proctitis. In the active stage of both diseases, circulating complement receptor positive cells were increased whereas T-cell percentages and lymphocyte functions were decreased. In severe forms of ulcerative colitis and idiopathic proctitis circulating EAC-phagocytosing esterase positive cells, indicative of activated monocytes, were demonstrated. Successful treatment with salicylazosulfapyridine (SASP) reversed these immunological changes. Incubation of SASP and its metabolites with leucocytes from patients and control subjects, in concentration similar to those demonstrated in sera from patients treated with SASP, did not alter the immunological changes.

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