Comorbid pain and migraine chronicity the Chronic Migraine Epidemiology and Outcomes Study

Ann I. Scher, Dawn C. Buse, Kristina M. Fanning, Amanda M. Kelly, Dana A. Franznick, Aubrey M. Adams, Richard B. Lipton

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Objective: To identify patterns of noncephalic pain comorbidity in people with episodic migraine (EM; ,15 headache-days per month) and chronic migraine (CM; 15 headache-days per month) and to examine whether the presence of noncephalic pain is an indicator for the 3-month onset or persistence of CM. Methods: Data from the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study, a prospective, web-based study with cross-sectional modules embedded in a longitudinal design, were analyzed at baseline and the 3-month follow-up. Relationships between the number of noncephalic pain sites and 3-month onset of CM or persistent CM were assessed. Results: Of 8,908 eligible respondents, 8,139 (91.4%) had EM and 769 (8.6%) had CM at baseline. At 3 months, the incidence of CM among those with baseline EM was 3.4%. When adjusted for demographics and headache-day frequency, the odds of CM onset among those with baseline EM increased by 30% (95% confidence interval [CI] 1.21-1.40, p , 0.001) for each additional noncephalic pain site at baseline. Among those with CM at baseline, 50.1% had persistent CM at the 3-month follow-up. After adjustment for demographics, individuals with CM were 15% (95% CI 1.07-1.25, p , 0.001) more likely to have persistent CM for each additional noncephalic pain site at baseline.

Original languageEnglish (US)
Pages (from-to)461-468
Number of pages8
JournalNeurology
Volume89
Issue number5
DOIs
StatePublished - Aug 1 2017

ASJC Scopus subject areas

  • Clinical Neurology

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    Scher, A. I., Buse, D. C., Fanning, K. M., Kelly, A. M., Franznick, D. A., Adams, A. M., & Lipton, R. B. (2017). Comorbid pain and migraine chronicity the Chronic Migraine Epidemiology and Outcomes Study. Neurology, 89(5), 461-468. https://doi.org/10.1212/WNL.0000000000004177