Community-acquired methicillin-resistant staphylococcus aureus in children with no identified predisposing risk

Betsy C. Herold, Lilly C. Immergluck, Melinda C. Maranan, Diane S. Lauderdale, Ryan E. Gaskin, Susan Boyle-Vavra, Cindy D. Leitch, Robert S. Daum

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1200 Scopus citations

Abstract

Context.-Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections in children have occurred primarily in individuals with recognized predisposing risks. Community-acquired MRSA infections in the absence of identified risk factors have been reported infrequently. Objectives.-To determine whether community-acquired MRSA infections in children with no identified predisposing risks are increasing and to define the spectrum of disease associated with MRSA isolation. Design.-Retrospective review of medical records. Patients.-Hospitalized children with S aureus isolated between August 1988 and July 1990 (1988-1990) and between August 1993 and July 1995 (1993-1995). Setting.-The University of Chicago Children's Hospital. Main Outcome Measures.-Prevalence of community-acquired MRSA over time, infecting vs colonizing isolates, and risk factors for disease. Results.-The number of children hospitalized with community-acquired MRSA disease increased from 8 in 1988-1990 to 35 in 1993-1995. Moreover, the prevalence of community-acquired MRSA without identified risk increased from 10 per 100 000 admissions in 1988-1990 to 259 per 100 000 admissions in 1993- 1995 (P<.001), and a greater proportion of isolates produced clinical infection. The clinical syndromes associated with MRSA in children without identified risk were similar to those associated with community-acquired methicillin-susceptible S aureus. Notably, 7 (70%) of 10 community-acquired MRSA isolates obtained from children with an identified risk were nonsusceptible to at least 2 drugs, compared with only 6 (24%) of 25 isolates obtained from children Without an identified risk (P=.02). Conclusions.- These findings demonstrate that the prevalence of community-acquired MRSA among children without identified risk factors is increasing.

Original languageEnglish (US)
Pages (from-to)593-598
Number of pages6
JournalJournal of the American Medical Association
Volume279
Issue number8
DOIs
StatePublished - Feb 25 1998
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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Herold, B. C., Immergluck, L. C., Maranan, M. C., Lauderdale, D. S., Gaskin, R. E., Boyle-Vavra, S., Leitch, C. D., & Daum, R. S. (1998). Community-acquired methicillin-resistant staphylococcus aureus in children with no identified predisposing risk. Journal of the American Medical Association, 279(8), 593-598. https://doi.org/10.1001/jama.279.8.593