Common diseases alter the physiological age-related blood microRNA profile

Tobias Fehlmann; Benoit Lehallier; Nicholas Schaum; Oliver Hahn; Mustafa Kahraman; Yongping Li; Nadja Grammes; Lars Geffers; Christina Backes; Rudi Balling; Fabian Kern; Rejko Krüger; Frank Lammert; Nicole Ludwig; Benjamin Meder; Bastian Fromm; Walter Maetzler; Daniela Berg; Kathrin Brockmann; Christian Deuschle; Anna Katharina von Thaler; Gerhard W. Eschweiler; Sofiya Milman; Nir Barziliai; Matthias Reichert; Tony Wyss-Coray; Eckart Meese; Andreas Keller

doi:10.1038/s41467-020-19665-1

Common diseases alter the physiological age-related blood microRNA profile

Tobias Fehlmann, Benoit Lehallier, Nicholas Schaum, Oliver Hahn, Mustafa Kahraman, Yongping Li, Nadja Grammes, Lars Geffers, Christina Backes, Rudi Balling, Fabian Kern, Rejko Krüger, Frank Lammert, Nicole Ludwig, Benjamin Meder, Bastian Fromm, Walter Maetzler, Daniela Berg, Kathrin Brockmann, Christian DeuschleAnna Katharina von Thaler, Gerhard W. Eschweiler, Sofiya Milman, Nir Barziliai, Matthias Reichert, Tony Wyss-Coray, Eckart Meese, Andreas Keller

Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.

Original language	English (US)
Article number	5958
Journal	Nature communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-19665-1
State	Published - Dec 2020

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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10.1038/s41467-020-19665-1

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Fehlmann, T., Lehallier, B., Schaum, N., Hahn, O., Kahraman, M., Li, Y., Grammes, N., Geffers, L., Backes, C., Balling, R., Kern, F., Krüger, R., Lammert, F., Ludwig, N., Meder, B., Fromm, B., Maetzler, W., Berg, D., Brockmann, K., ... Keller, A. (2020). Common diseases alter the physiological age-related blood microRNA profile. Nature communications, 11(1), [5958]. https://doi.org/10.1038/s41467-020-19665-1

Fehlmann, T, Lehallier, B, Schaum, N, Hahn, O, Kahraman, M, Li, Y, Grammes, N, Geffers, L, Backes, C, Balling, R, Kern, F, Krüger, R, Lammert, F, Ludwig, N, Meder, B, Fromm, B, Maetzler, W, Berg, D, Brockmann, K, Deuschle, C, von Thaler, AK, Eschweiler, GW, Milman, S, Barziliai, N, Reichert, M, Wyss-Coray, T, Meese, E & Keller, A 2020, 'Common diseases alter the physiological age-related blood microRNA profile', Nature communications, vol. 11, no. 1, 5958. https://doi.org/10.1038/s41467-020-19665-1

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abstract = "Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5{\textquoteright} mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.",

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AU - Li, Yongping

AU - Grammes, Nadja

AU - Geffers, Lars

AU - Backes, Christina

AU - Balling, Rudi

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AU - Krüger, Rejko

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AU - Ludwig, Nicole

AU - Meder, Benjamin

AU - Fromm, Bastian

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AU - Brockmann, Kathrin

AU - Deuschle, Christian

AU - von Thaler, Anna Katharina

AU - Eschweiler, Gerhard W.

AU - Milman, Sofiya

AU - Barziliai, Nir

AU - Reichert, Matthias

AU - Wyss-Coray, Tony

AU - Meese, Eckart

AU - Keller, Andreas

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Common diseases alter the physiological age-related blood microRNA profile

Abstract

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