TY - JOUR
T1 - Colloidal gold
T2 - a novel nanoparticle for targeted cancer therapeutics.
AU - Powell, Anathea C.
AU - Paciotti, Giulio F.
AU - Libutti, Steven K.
PY - 2010
Y1 - 2010
N2 - Since their initial description in 1857, gold nanoparticles have been used extensively in the fields of diagnostics and therapeutics. Now, gold nanoparticles are engineered to target the delivery of potent anti-cancer therapeutics to solid tumors to improve either their safety or efficacy or both. Described in this chapter is the development of one such nanotherapeutic, termed CYT-6091, that targets the delivery of tumor necrosis factor alpha (TNF) to solid tumors. Outlined in the presentation is a discussion of nanoparticles and specifically colloidal gold, an historical review on the biology of TNF and its limited use in the clinic when administered systemically, and finally, how gold nanoparticles bound with TNF may improve the safety and efficacy profiles of TNF.
AB - Since their initial description in 1857, gold nanoparticles have been used extensively in the fields of diagnostics and therapeutics. Now, gold nanoparticles are engineered to target the delivery of potent anti-cancer therapeutics to solid tumors to improve either their safety or efficacy or both. Described in this chapter is the development of one such nanotherapeutic, termed CYT-6091, that targets the delivery of tumor necrosis factor alpha (TNF) to solid tumors. Outlined in the presentation is a discussion of nanoparticles and specifically colloidal gold, an historical review on the biology of TNF and its limited use in the clinic when administered systemically, and finally, how gold nanoparticles bound with TNF may improve the safety and efficacy profiles of TNF.
UR - http://www.scopus.com/inward/record.url?scp=77953466025&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953466025&partnerID=8YFLogxK
U2 - 10.1007/978-1-60761-609-2_25
DO - 10.1007/978-1-60761-609-2_25
M3 - Review article
C2 - 20217609
AN - SCOPUS:77953466025
SN - 1064-3745
VL - 624
SP - 375
EP - 384
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
ER -
