Coiled-coils in phage display screening: Insight into exceptional selectivity provided by molecular dynamics

Jérémie Mortier, Elisabeth K. Nyakatura, Oliver Reimann, Susanne Huhmann, Jan O. Daldrop, Carsten Baldauf, Gerhard Wolber, Markus S. Miettinen, Beate Koksch

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Involved in numerous key biological functions, protein helix-helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the ±-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalJournal of Chemical Information and Modeling
Volume55
Issue number3
DOIs
StatePublished - Mar 23 2015
Externally publishedYes

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Bacteriophages
Pattern recognition
Molecular dynamics
Screening
Display devices
Proteins
interaction
pattern recognition

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Computer Science Applications
  • Library and Information Sciences

Cite this

Coiled-coils in phage display screening : Insight into exceptional selectivity provided by molecular dynamics. / Mortier, Jérémie; Nyakatura, Elisabeth K.; Reimann, Oliver; Huhmann, Susanne; Daldrop, Jan O.; Baldauf, Carsten; Wolber, Gerhard; Miettinen, Markus S.; Koksch, Beate.

In: Journal of Chemical Information and Modeling, Vol. 55, No. 3, 23.03.2015, p. 495-500.

Research output: Contribution to journalArticle

Mortier, J, Nyakatura, EK, Reimann, O, Huhmann, S, Daldrop, JO, Baldauf, C, Wolber, G, Miettinen, MS & Koksch, B 2015, 'Coiled-coils in phage display screening: Insight into exceptional selectivity provided by molecular dynamics', Journal of Chemical Information and Modeling, vol. 55, no. 3, pp. 495-500. https://doi.org/10.1021/ci500689c
Mortier, Jérémie ; Nyakatura, Elisabeth K. ; Reimann, Oliver ; Huhmann, Susanne ; Daldrop, Jan O. ; Baldauf, Carsten ; Wolber, Gerhard ; Miettinen, Markus S. ; Koksch, Beate. / Coiled-coils in phage display screening : Insight into exceptional selectivity provided by molecular dynamics. In: Journal of Chemical Information and Modeling. 2015 ; Vol. 55, No. 3. pp. 495-500.
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