Cognitive impairment and sensory loss associated with chronic low-level ethylene oxide exposure

H. A. Crystal, H. H. Schaumburg, E. Grober, P. A. Fuld, Richard B. Lipton

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A 29-year-old college graduate worked for 10 years adjacent to an ethylene oxide (EtO) chemical sterilizer. When the sterilizer was closed, levels of EtO in the air around the sterilizer were 4.2 ppm (OSHA maximum level, 1 ppm). Seven years after beginning work with EtO, she experienced impaired memory, increased imtability, clumsiness, and falling. Three years later exposure ceased, and symptoms markedly improved over the next few months, but did not disappear entirely. Neurologic and neuropsychological exams 1 year after exposure ceased demonstrated emotional lability, impaired concentration, cognitive slowing, impaired recent and remote memory, and impaired thermal and vibratory sense in distal limbs. Her pattern of relatively preserved learning and Frofound forgetting distinguished her from most other subjects with memory disorders. No other causes for the condition wefe identified.

Original languageEnglish (US)
Pages (from-to)567-569
Number of pages3
JournalNeurology
Volume38
Issue number4
StatePublished - 1988

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Ethylene Oxide
United States Occupational Safety and Health Administration
Long-Term Memory
Memory Disorders
Nervous System
Extremities
Hot Temperature
Air
Learning
Cognitive Dysfunction
Cognitive Impairment

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Crystal, H. A., Schaumburg, H. H., Grober, E., Fuld, P. A., & Lipton, R. B. (1988). Cognitive impairment and sensory loss associated with chronic low-level ethylene oxide exposure. Neurology, 38(4), 567-569.

Cognitive impairment and sensory loss associated with chronic low-level ethylene oxide exposure. / Crystal, H. A.; Schaumburg, H. H.; Grober, E.; Fuld, P. A.; Lipton, Richard B.

In: Neurology, Vol. 38, No. 4, 1988, p. 567-569.

Research output: Contribution to journalArticle

Crystal, HA, Schaumburg, HH, Grober, E, Fuld, PA & Lipton, RB 1988, 'Cognitive impairment and sensory loss associated with chronic low-level ethylene oxide exposure', Neurology, vol. 38, no. 4, pp. 567-569.
Crystal, H. A. ; Schaumburg, H. H. ; Grober, E. ; Fuld, P. A. ; Lipton, Richard B. / Cognitive impairment and sensory loss associated with chronic low-level ethylene oxide exposure. In: Neurology. 1988 ; Vol. 38, No. 4. pp. 567-569.
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