Coffee, tea, and sugar-sweetened carbonated soft drink intake and pancreatic cancer risk

A pooled analysis of 14 cohort studies

Jeanine M. Genkinger, Ruifeng Li, Donna Spiegelman, Kristin E. Anderson, Demetrius Albanes, Leif Bergkvist, Leslie Bernstein, Amanda Black, Piet A. Van Den Brandt, Dallas R. English, Jo L. Freudenheim, Charles S. Fuchs, Graham G. Giles, Edward Giovannucci, R. Alexandra Goldbohm, Pamela L. Horn-Ross, Eric J. Jacobs, Anita Koushik, Satu Männisö, James R. Marshall & 9 others Anthony B. Miller, Alpa V. Patel, Kim Robien, Thomas E. Rohan, Catherine Schairer, Rachael Stolzenberg-Solomon, Alicja Wolk, Regina G. Ziegler, Stephanie A. Smith-Warner

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: Coffee has been hypothesized to have pro- and anticarcinogenic properties, whereas tea may contain anticarcinogenic compounds. Studies assessing coffee intake and pancreatic cancer risk have yielded mixed results, whereas findings for tea intake have mostly been null. Sugar-sweetened carbonated soft drink (SSB) intake has been associated with higher circulating levels of insulin, which may promote carcinogenesis. Few prospective studies have examined SSB intake and pancreatic cancer risk; results have been heterogeneous. Methods: In this pooled analysis from 14 prospective cohort studies, 2,185 incident pancreatic cancer cases were identified among 853,894 individuals during follow-up. Multivariate (MV) study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards models and then pooled using a random-effects model. Results: No statistically significant associations were observed between pancreatic cancer risk and intake of coffee (MVRR = 1.10; 95% CI, 0.81-1.48 comparing ≥900 to <0 g/d; 237g ≈ 8oz), tea (MVRR = 0.96; 95% CI, 0.78-1.16 comparing ≥400 to 0 g/d; 237g ≈ 8oz), or SSB (MVRR = 1.19; 95% CI, 0.98-1.46 comparing ≥250 to 0 g/d; 355g ≈ 12oz; P value, test for between-studies heterogeneity > 0.05). These associations were consistent across levels of sex, smoking status, and body mass index. When modeled as a continuous variable, a positive association was evident for SSB (MVRR = 1.06; 95% CI, 1.02-1.12). Conclusion and Impact: Overall, no associations were observed for intakes of coffee or tea during adulthood and pancreatic cancer risk. Although we were only able to examine modest intake of SSB, there was a suggestive, modest positive association for risk of pancreatic cancer for intakes of SSB.

Original languageEnglish (US)
Pages (from-to)305-318
Number of pages14
JournalCancer Epidemiology Biomarkers and Prevention
Volume21
Issue number2
DOIs
StatePublished - Feb 2012

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Carbonated Beverages
Coffee
Tea
Pancreatic Neoplasms
Cohort Studies
Confidence Intervals
Prospective Studies
Proportional Hazards Models
Carcinogenesis
Body Mass Index
Smoking
Insulin

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Coffee, tea, and sugar-sweetened carbonated soft drink intake and pancreatic cancer risk : A pooled analysis of 14 cohort studies. / Genkinger, Jeanine M.; Li, Ruifeng; Spiegelman, Donna; Anderson, Kristin E.; Albanes, Demetrius; Bergkvist, Leif; Bernstein, Leslie; Black, Amanda; Van Den Brandt, Piet A.; English, Dallas R.; Freudenheim, Jo L.; Fuchs, Charles S.; Giles, Graham G.; Giovannucci, Edward; Goldbohm, R. Alexandra; Horn-Ross, Pamela L.; Jacobs, Eric J.; Koushik, Anita; Männisö, Satu; Marshall, James R.; Miller, Anthony B.; Patel, Alpa V.; Robien, Kim; Rohan, Thomas E.; Schairer, Catherine; Stolzenberg-Solomon, Rachael; Wolk, Alicja; Ziegler, Regina G.; Smith-Warner, Stephanie A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 21, No. 2, 02.2012, p. 305-318.

Research output: Contribution to journalArticle

Genkinger, JM, Li, R, Spiegelman, D, Anderson, KE, Albanes, D, Bergkvist, L, Bernstein, L, Black, A, Van Den Brandt, PA, English, DR, Freudenheim, JL, Fuchs, CS, Giles, GG, Giovannucci, E, Goldbohm, RA, Horn-Ross, PL, Jacobs, EJ, Koushik, A, Männisö, S, Marshall, JR, Miller, AB, Patel, AV, Robien, K, Rohan, TE, Schairer, C, Stolzenberg-Solomon, R, Wolk, A, Ziegler, RG & Smith-Warner, SA 2012, 'Coffee, tea, and sugar-sweetened carbonated soft drink intake and pancreatic cancer risk: A pooled analysis of 14 cohort studies', Cancer Epidemiology Biomarkers and Prevention, vol. 21, no. 2, pp. 305-318. https://doi.org/10.1158/1055-9965.EPI-11-0945-T
Genkinger, Jeanine M. ; Li, Ruifeng ; Spiegelman, Donna ; Anderson, Kristin E. ; Albanes, Demetrius ; Bergkvist, Leif ; Bernstein, Leslie ; Black, Amanda ; Van Den Brandt, Piet A. ; English, Dallas R. ; Freudenheim, Jo L. ; Fuchs, Charles S. ; Giles, Graham G. ; Giovannucci, Edward ; Goldbohm, R. Alexandra ; Horn-Ross, Pamela L. ; Jacobs, Eric J. ; Koushik, Anita ; Männisö, Satu ; Marshall, James R. ; Miller, Anthony B. ; Patel, Alpa V. ; Robien, Kim ; Rohan, Thomas E. ; Schairer, Catherine ; Stolzenberg-Solomon, Rachael ; Wolk, Alicja ; Ziegler, Regina G. ; Smith-Warner, Stephanie A. / Coffee, tea, and sugar-sweetened carbonated soft drink intake and pancreatic cancer risk : A pooled analysis of 14 cohort studies. In: Cancer Epidemiology Biomarkers and Prevention. 2012 ; Vol. 21, No. 2. pp. 305-318.
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abstract = "Background: Coffee has been hypothesized to have pro- and anticarcinogenic properties, whereas tea may contain anticarcinogenic compounds. Studies assessing coffee intake and pancreatic cancer risk have yielded mixed results, whereas findings for tea intake have mostly been null. Sugar-sweetened carbonated soft drink (SSB) intake has been associated with higher circulating levels of insulin, which may promote carcinogenesis. Few prospective studies have examined SSB intake and pancreatic cancer risk; results have been heterogeneous. Methods: In this pooled analysis from 14 prospective cohort studies, 2,185 incident pancreatic cancer cases were identified among 853,894 individuals during follow-up. Multivariate (MV) study-specific relative risks (RR) and 95{\%} confidence intervals (CI) were calculated using Cox proportional hazards models and then pooled using a random-effects model. Results: No statistically significant associations were observed between pancreatic cancer risk and intake of coffee (MVRR = 1.10; 95{\%} CI, 0.81-1.48 comparing ≥900 to <0 g/d; 237g ≈ 8oz), tea (MVRR = 0.96; 95{\%} CI, 0.78-1.16 comparing ≥400 to 0 g/d; 237g ≈ 8oz), or SSB (MVRR = 1.19; 95{\%} CI, 0.98-1.46 comparing ≥250 to 0 g/d; 355g ≈ 12oz; P value, test for between-studies heterogeneity > 0.05). These associations were consistent across levels of sex, smoking status, and body mass index. When modeled as a continuous variable, a positive association was evident for SSB (MVRR = 1.06; 95{\%} CI, 1.02-1.12). Conclusion and Impact: Overall, no associations were observed for intakes of coffee or tea during adulthood and pancreatic cancer risk. Although we were only able to examine modest intake of SSB, there was a suggestive, modest positive association for risk of pancreatic cancer for intakes of SSB.",
author = "Genkinger, {Jeanine M.} and Ruifeng Li and Donna Spiegelman and Anderson, {Kristin E.} and Demetrius Albanes and Leif Bergkvist and Leslie Bernstein and Amanda Black and {Van Den Brandt}, {Piet A.} and English, {Dallas R.} and Freudenheim, {Jo L.} and Fuchs, {Charles S.} and Giles, {Graham G.} and Edward Giovannucci and Goldbohm, {R. Alexandra} and Horn-Ross, {Pamela L.} and Jacobs, {Eric J.} and Anita Koushik and Satu M{\"a}nnis{\"o} and Marshall, {James R.} and Miller, {Anthony B.} and Patel, {Alpa V.} and Kim Robien and Rohan, {Thomas E.} and Catherine Schairer and Rachael Stolzenberg-Solomon and Alicja Wolk and Ziegler, {Regina G.} and Smith-Warner, {Stephanie A.}",
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T1 - Coffee, tea, and sugar-sweetened carbonated soft drink intake and pancreatic cancer risk

T2 - A pooled analysis of 14 cohort studies

AU - Genkinger, Jeanine M.

AU - Li, Ruifeng

AU - Spiegelman, Donna

AU - Anderson, Kristin E.

AU - Albanes, Demetrius

AU - Bergkvist, Leif

AU - Bernstein, Leslie

AU - Black, Amanda

AU - Van Den Brandt, Piet A.

AU - English, Dallas R.

AU - Freudenheim, Jo L.

AU - Fuchs, Charles S.

AU - Giles, Graham G.

AU - Giovannucci, Edward

AU - Goldbohm, R. Alexandra

AU - Horn-Ross, Pamela L.

AU - Jacobs, Eric J.

AU - Koushik, Anita

AU - Männisö, Satu

AU - Marshall, James R.

AU - Miller, Anthony B.

AU - Patel, Alpa V.

AU - Robien, Kim

AU - Rohan, Thomas E.

AU - Schairer, Catherine

AU - Stolzenberg-Solomon, Rachael

AU - Wolk, Alicja

AU - Ziegler, Regina G.

AU - Smith-Warner, Stephanie A.

PY - 2012/2

Y1 - 2012/2

N2 - Background: Coffee has been hypothesized to have pro- and anticarcinogenic properties, whereas tea may contain anticarcinogenic compounds. Studies assessing coffee intake and pancreatic cancer risk have yielded mixed results, whereas findings for tea intake have mostly been null. Sugar-sweetened carbonated soft drink (SSB) intake has been associated with higher circulating levels of insulin, which may promote carcinogenesis. Few prospective studies have examined SSB intake and pancreatic cancer risk; results have been heterogeneous. Methods: In this pooled analysis from 14 prospective cohort studies, 2,185 incident pancreatic cancer cases were identified among 853,894 individuals during follow-up. Multivariate (MV) study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards models and then pooled using a random-effects model. Results: No statistically significant associations were observed between pancreatic cancer risk and intake of coffee (MVRR = 1.10; 95% CI, 0.81-1.48 comparing ≥900 to <0 g/d; 237g ≈ 8oz), tea (MVRR = 0.96; 95% CI, 0.78-1.16 comparing ≥400 to 0 g/d; 237g ≈ 8oz), or SSB (MVRR = 1.19; 95% CI, 0.98-1.46 comparing ≥250 to 0 g/d; 355g ≈ 12oz; P value, test for between-studies heterogeneity > 0.05). These associations were consistent across levels of sex, smoking status, and body mass index. When modeled as a continuous variable, a positive association was evident for SSB (MVRR = 1.06; 95% CI, 1.02-1.12). Conclusion and Impact: Overall, no associations were observed for intakes of coffee or tea during adulthood and pancreatic cancer risk. Although we were only able to examine modest intake of SSB, there was a suggestive, modest positive association for risk of pancreatic cancer for intakes of SSB.

AB - Background: Coffee has been hypothesized to have pro- and anticarcinogenic properties, whereas tea may contain anticarcinogenic compounds. Studies assessing coffee intake and pancreatic cancer risk have yielded mixed results, whereas findings for tea intake have mostly been null. Sugar-sweetened carbonated soft drink (SSB) intake has been associated with higher circulating levels of insulin, which may promote carcinogenesis. Few prospective studies have examined SSB intake and pancreatic cancer risk; results have been heterogeneous. Methods: In this pooled analysis from 14 prospective cohort studies, 2,185 incident pancreatic cancer cases were identified among 853,894 individuals during follow-up. Multivariate (MV) study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards models and then pooled using a random-effects model. Results: No statistically significant associations were observed between pancreatic cancer risk and intake of coffee (MVRR = 1.10; 95% CI, 0.81-1.48 comparing ≥900 to <0 g/d; 237g ≈ 8oz), tea (MVRR = 0.96; 95% CI, 0.78-1.16 comparing ≥400 to 0 g/d; 237g ≈ 8oz), or SSB (MVRR = 1.19; 95% CI, 0.98-1.46 comparing ≥250 to 0 g/d; 355g ≈ 12oz; P value, test for between-studies heterogeneity > 0.05). These associations were consistent across levels of sex, smoking status, and body mass index. When modeled as a continuous variable, a positive association was evident for SSB (MVRR = 1.06; 95% CI, 1.02-1.12). Conclusion and Impact: Overall, no associations were observed for intakes of coffee or tea during adulthood and pancreatic cancer risk. Although we were only able to examine modest intake of SSB, there was a suggestive, modest positive association for risk of pancreatic cancer for intakes of SSB.

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