Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma

S. Xiao, D. Li, J. M. Corson, Jan Vijg, J. A. Fletcher

Research output: Contribution to journalArticle

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Abstract

Chromosome band 9p21 is deleted frequently in non-small cell lung carcinoma (NSCLC), and the p15 and p16 cyclin-dependent kinase-4 inhibitor genes map within this deletion region. Recent studies demonstrated deletion of p15 and p16 in NSCLC metastases and cell lines, suggesting a rifle for these genes in NSCLC progression. We now report p15 and p16 copy number, as determined by fluorescence in situ hybridization with a P1 contig, in 18 primary NSCLCs. Codeletion of p15 and p16 was found in 15 of 18 NSCLCs, and 1 of the 3 tumors with normal p15 and p16 copy number had a nonsense mutation in exon 2 nf p16. We conclude that p15 and p16 are deleted and/or mutated in most primary NSCLCs. Two observations, however, support the involvement of at least one additional tumor suppressor gene on chromosome 9. These observations are: (a) the large size (>100 kb) of most NSCLC p15/p16 deletions; and (b) the absence of exon 2 mutations in most retained NSCLC p15 and p16 alleles.

Original languageEnglish (US)
Pages (from-to)2968-2971
Number of pages4
JournalCancer Research
Volume55
Issue number14
StatePublished - 1995
Externally publishedYes

Fingerprint

p16 Genes
Non-Small Cell Lung Carcinoma
Exons
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase 4
Chromosomes, Human, Pair 9
Nonsense Codon
Firearms
Tumor Suppressor Genes
Fluorescence In Situ Hybridization
Genes
Chromosomes
Alleles
Neoplasm Metastasis
Cell Line
Mutation
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Xiao, S., Li, D., Corson, J. M., Vijg, J., & Fletcher, J. A. (1995). Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma. Cancer Research, 55(14), 2968-2971.

Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma. / Xiao, S.; Li, D.; Corson, J. M.; Vijg, Jan; Fletcher, J. A.

In: Cancer Research, Vol. 55, No. 14, 1995, p. 2968-2971.

Research output: Contribution to journalArticle

Xiao, S, Li, D, Corson, JM, Vijg, J & Fletcher, JA 1995, 'Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma', Cancer Research, vol. 55, no. 14, pp. 2968-2971.
Xiao S, Li D, Corson JM, Vijg J, Fletcher JA. Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma. Cancer Research. 1995;55(14):2968-2971.
Xiao, S. ; Li, D. ; Corson, J. M. ; Vijg, Jan ; Fletcher, J. A. / Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma. In: Cancer Research. 1995 ; Vol. 55, No. 14. pp. 2968-2971.
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