Clusters, bundles, arrays and lattices: Novel mechanisms for lectin-saccharide-mediated cellular interactions

C. Fred Brewer, M. Carrie Miceli, Linda G. Baum

Research output: Contribution to journalReview article

331 Scopus citations

Abstract

Multivalent protein-carbohydrate interactions regulate essential cellular events, including cell proliferation, adhesion and death. These multivalent interactions can create homogeneous complexes of lectins, such as the galectins, with their saccharide ligands. Lectin-saccharide complexes can concentrate specific glycoproteins or glycolipids within the lattice, while excluding other cell surface molecules. The formation of lectin-saccharide lattices on the cell surface can thus organize the plasma membrane into specialized domains that perform unique functions.

Original languageEnglish (US)
Pages (from-to)616-623
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume12
Issue number5
DOIs
StatePublished - Oct 1 2002

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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