TY - JOUR
T1 - Clusters, bundles, arrays and lattices
T2 - Novel mechanisms for lectin-saccharide-mediated cellular interactions
AU - Brewer, C. Fred
AU - Miceli, M. Carrie
AU - Baum, Linda G.
N1 - Funding Information:
We thank members of the Brewer, Miceli and Baum laboratories for contributions to the work described here, and LD Powell for critically reading the manuscript. Supported in part by National Institutes of Health (NIH) grant GM63281, Department of Defense grant 17-02-1-0022 and a Cancer Research Institute grant to LG Baum, NIH grant CA16054 to CF Brewer, and NIH grant CA65979 and an Arthritis Foundation Research Grant to MC Miceli.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - Multivalent protein-carbohydrate interactions regulate essential cellular events, including cell proliferation, adhesion and death. These multivalent interactions can create homogeneous complexes of lectins, such as the galectins, with their saccharide ligands. Lectin-saccharide complexes can concentrate specific glycoproteins or glycolipids within the lattice, while excluding other cell surface molecules. The formation of lectin-saccharide lattices on the cell surface can thus organize the plasma membrane into specialized domains that perform unique functions.
AB - Multivalent protein-carbohydrate interactions regulate essential cellular events, including cell proliferation, adhesion and death. These multivalent interactions can create homogeneous complexes of lectins, such as the galectins, with their saccharide ligands. Lectin-saccharide complexes can concentrate specific glycoproteins or glycolipids within the lattice, while excluding other cell surface molecules. The formation of lectin-saccharide lattices on the cell surface can thus organize the plasma membrane into specialized domains that perform unique functions.
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U2 - 10.1016/S0959-440X(02)00364-0
DO - 10.1016/S0959-440X(02)00364-0
M3 - Review article
C2 - 12464313
AN - SCOPUS:0036816147
SN - 0959-440X
VL - 12
SP - 616
EP - 623
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 5
ER -