Cluster attacks responsive to recreational cannabis and dronabinol

Matthew S. Robbins, Sara Tarshish, Seymour Solomon, Brian M. Grosberg

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Pharmacological preparations of cannabinoid compounds have a variety of therapeutic uses in medicine, including different pain syndromes, but have not been previously reported as beneficial for cluster headache. We present a patient with cluster headache who was refractory to multiple acute and preventive medications but successfully aborted his attacks with recreational marijuana use; subsequent use of dronabinol provided equally effective pain relief. The beneficial effect may be related to the high concentration of cannabinoid receptors in the hypothalamus, which has been implicated as a site of dysfunction in neuroimaging studies of patients with cluster headache.

Original languageEnglish (US)
Pages (from-to)914-916
Number of pages3
Issue number6
StatePublished - Jun 2009


  • Cannabis
  • Cluster headache
  • Dronabinol

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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