Clostridium difcile-associated diseases

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Clostridium difficile is the most common and important cause of healthcare infection, manifesting as a spectrum of disease ranging from mild diarrhea to toxic megacolon and pseudomembranous colitis. The causative organism, an anaerobic spore-forming bacillus, particularly affects people who have received antibiotics in the recent past; additional predispositions besides older age include immune suppressed states, gastric surgery, tube feeding, and chronic kidney disease. The geriatric population is vulnerable to complications and mortality. A variety of stool assays help in diagnosis. Prevention is the key, with infection control measures and meticulous hand hygiene important. Initial therapy includes use of metronidazole or vancomycin. Resistance and recurrence are handled differently. Newer drugs, monoclonal antibodies, and vaccines may offer better options in future.

Original languageEnglish (US)
Title of host publicationGeriatric Gastroenterology
PublisherSpringer New York
Pages519-526
Number of pages8
ISBN (Print)9781441916235, 9781441916228
DOIs
StatePublished - Jan 1 2012

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Toxic Megacolon
Pseudomembranous Enterocolitis
Hand Hygiene
Clostridium difficile
Clostridium
Metronidazole
Enteral Nutrition
Vulnerable Populations
Vancomycin
Infection Control
Spores
Chronic Renal Insufficiency
Geriatrics
Bacillus
Diarrhea
Vaccines
Monoclonal Antibodies
Anti-Bacterial Agents
Delivery of Health Care
Recurrence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pitchumoni, C. S., & Dharmarajan, T. S. (2012). Clostridium difcile-associated diseases. In Geriatric Gastroenterology (pp. 519-526). Springer New York. https://doi.org/10.1007/978-1-4419-1623-5_54

Clostridium difcile-associated diseases. / Pitchumoni, C. S.; Dharmarajan, Thiruvinvamalai S.

Geriatric Gastroenterology. Springer New York, 2012. p. 519-526.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pitchumoni, CS & Dharmarajan, TS 2012, Clostridium difcile-associated diseases. in Geriatric Gastroenterology. Springer New York, pp. 519-526. https://doi.org/10.1007/978-1-4419-1623-5_54
Pitchumoni CS, Dharmarajan TS. Clostridium difcile-associated diseases. In Geriatric Gastroenterology. Springer New York. 2012. p. 519-526 https://doi.org/10.1007/978-1-4419-1623-5_54
Pitchumoni, C. S. ; Dharmarajan, Thiruvinvamalai S. / Clostridium difcile-associated diseases. Geriatric Gastroenterology. Springer New York, 2012. pp. 519-526
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