Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.

Edith P. Mitchell, Roman Perez-Soler, Eric Van Cutsem, Mario E. Lacouture

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.

Original languageEnglish (US)
Pages (from-to)4-9
Number of pages6
JournalOncology (Williston Park, N.Y.)
Volume21
Issue number11 Suppl 5
StatePublished - Oct 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Mitchell, E. P., Perez-Soler, R., Van Cutsem, E., & Lacouture, M. E. (2007). Clinical presentation and pathophysiology of EGFRI dermatologic toxicities. Oncology (Williston Park, N.Y.), 21(11 Suppl 5), 4-9.