Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.

Edith P. Mitchell; Roman Perez-Soler; Eric Van Cutsem; Mario E. Lacouture

Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.

Edith P. Mitchell, Roman Perez-Soler, Eric Van Cutsem, Mario E. Lacouture

Research output: Contribution to journal › Review article › peer-review

Abstract

This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.

Original language	English (US)
Pages (from-to)	4-9
Number of pages	6
Journal	Oncology (Williston Park, N.Y.)
Volume	21
Issue number	11 Suppl 5
State	Published - Oct 2007
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.",

abstract = "This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.",

author = "Mitchell, {Edith P.} and Roman Perez-Soler and {Van Cutsem}, Eric and Lacouture, {Mario E.}",

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AU - Perez-Soler, Roman

AU - Van Cutsem, Eric

AU - Lacouture, Mario E.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2007/10

Y1 - 2007/10

N2 - This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.

AB - This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.

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M3 - Review article

C2 - 18154212

AN - SCOPUS:38549149740

VL - 21

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JO - Oncology

JF - Oncology

SN - 0890-9091

IS - 11 Suppl 5

ER -

Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.

Abstract

ASJC Scopus subject areas

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