Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.

Edith P. Mitchell; Roman Perez-Soler; Eric Van Cutsem; Mario E. Lacouture

Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.

Edith P. Mitchell, Roman Perez-Soler, Eric Van Cutsem, Mario E. Lacouture

Medicine

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.

Original language	English (US)
Pages (from-to)	4-9
Number of pages	6
Journal	Oncology (Williston Park, N.Y.)
Volume	21
Issue number	11 Suppl 5
State	Published - Oct 2007

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.",

abstract = "This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.",

author = "Mitchell, {Edith P.} and Roman Perez-Soler and {Van Cutsem}, Eric and Lacouture, {Mario E.}",

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AU - Perez-Soler, Roman

AU - Van Cutsem, Eric

AU - Lacouture, Mario E.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2007/10

Y1 - 2007/10

N2 - This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.

AB - This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.

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