TY - JOUR
T1 - Climate change and epilepsy
T2 - Insights from clinical and basic science studies
AU - Gulcebi, Medine I.
AU - Bartolini, Emanuele
AU - Lee, Omay
AU - Lisgaras, Christos Panagiotis
AU - Onat, Filiz
AU - Mifsud, Janet
AU - Striano, Pasquale
AU - Vezzani, Annamaria
AU - Hildebrand, Michael S.
AU - Jimenez-Jimenez, Diego
AU - Junck, Larry
AU - Lewis-Smith, David
AU - Scheffer, Ingrid E.
AU - Thijs, Roland D.
AU - Zuberi, Sameer M.
AU - Blenkinsop, Stephen
AU - Fowler, Hayley J.
AU - Foley, Aideen
AU - Sisodiya, Sanjay M.
AU - Balestrini, Simona
AU - Berkovic, Samuel
AU - Cavalleri, Gianpiero
AU - Correa, Daniel José
AU - Martins Custodio, Helena
AU - Galovic, Marian
AU - Guerrini, Renzo
AU - Henshall, David
AU - Howard, Olga
AU - Hughes, Kelvin
AU - Katsarou, Anna
AU - Koeleman, Bobby P.C.
AU - Krause, Roland
AU - Lowenstein, Daniel
AU - Mandelenaki, Despoina
AU - Marini, Carla
AU - O'Brien, Terence J.
AU - Pace, Adrian
AU - De Palma, Luca
AU - Perucca, Piero
AU - Pitkänen, Asla
AU - Quinn, Finola
AU - Selmer, Kaja Kristine
AU - Steward, Charles A.
AU - Swanborough, Nicola
AU - Thijs, Roland
AU - Tittensor, Phil
AU - Trivisano, Marina
AU - Weckhuysen, Sarah
AU - Zara, Federico
N1 - Funding Information:
We are grateful to the Epilepsy Society for their support of this work, and funding to SMS. This work was partly carried out at NIHR University College London Hospitals Biomedical Research Centre, which receives a proportion of funding from the UK Department of Health’s NIHR Biomedical Research Centres funding scheme.
Funding Information:
We are grateful to the Epilepsy Society for their support of this work, and funding to SMS. This work was partly carried out at NIHR University College London Hospitals Biomedical Research Centre, which receives a proportion of funding from the UK Department of Health's NIHR Biomedical Research Centres funding scheme.
Funding Information:
PS has received speaker fees and participated at advisory boards for Biomarin, Zogenyx, GW Pharmaceuticals, and has received research funding by ENECTA BV, GW Pharmaceuticals, Kolfarma srl., Eisai. SMZ has received research funding from Epilepsy Research UK, Glasgow Children’s Hospital Charity, Dravet Syndrome UK and received honoraria for advisory boards/consultancy work/speaking at educational symposia from GW Pharma, Zogenix Ltd., Biocodex, UCB Pharma, Nutricia and Encoded Genomics. IES may accrue future revenue on pending patent WO61/010176 (filed: 2008): Therapeutic Compound; has a patent for SCN1A testing held by Bionomics Inc and licensed to various diagnostic companies; has a patent molecular diagnostic/theranostic target for benign familial infantile epilepsy (BFIE) [PRRT2] 2011904493 & 2012900190 and PCT/AU2012/001321 (TECH ID:2012-009) with royalties paid. She has served on scientific advisory boards for UCB, Eisai, GlaxoSmithKline, BioMarin, Nutricia, Rogcon and Xenon Pharmaceuticals; has received speaker honoraria from GlaxoSmithKline, UCB, BioMarin, Biocodex and Eisai; has received funding for travel from UCB, Biocodex, GlaxoSmithKline, Biomarin and Eisai; has served as an investigator for Zogenix, Zynerba, Ultragenyx, GW Pharma, UCB, Eisai, Anavex Life Sciences, Ovid Therapeutics, Epigenyx, Encoded Therapeutics and Marinus; and has consulted for Zynerba Pharmaceuticals, Atheneum Partners, Ovid Therapeutics, Epilepsy Consortium and UCB.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/3
Y1 - 2021/3
N2 - Climate change is with us. As professionals who place value on evidence-based practice, climate change is something we cannot ignore. The current pandemic of the novel coronavirus, SARS-CoV-2, has demonstrated how global crises can arise suddenly and have a significant impact on public health. Global warming, a chronic process punctuated by acute episodes of extreme weather events, is an insidious global health crisis needing at least as much attention. Many neurological diseases are complex chronic conditions influenced at many levels by changes in the environment. This review aimed to collate and evaluate reports from clinical and basic science about the relationship between climate change and epilepsy. The keywords climate change, seasonal variation, temperature, humidity, thermoregulation, biorhythm, gene, circadian rhythm, heat, and weather were used to search the published evidence. A number of climatic variables are associated with increased seizure frequency in people with epilepsy. Climate change-induced increase in seizure precipitants such as fevers, stress, and sleep deprivation (e.g. as a result of more frequent extreme weather events) or vector-borne infections may trigger or exacerbate seizures, lead to deterioration of seizure control, and affect neurological, cerebrovascular, or cardiovascular comorbidities and risk of sudden unexpected death in epilepsy. Risks are likely to be modified by many factors, ranging from individual genetic variation and temperature-dependent channel function, to housing quality and global supply chains. According to the results of the limited number of experimental studies with animal models of seizures or epilepsy, different seizure types appear to have distinct susceptibility to seasonal influences. Increased body temperature, whether in the context of fever or not, has a critical role in seizure threshold and seizure-related brain damage. Links between climate change and epilepsy are likely to be multifactorial, complex, and often indirect, which makes predictions difficult. We need more data on possible climate-driven altered risks for seizures, epilepsy, and epileptogenesis, to identify underlying mechanisms at systems, cellular, and molecular levels for better understanding of the impact of climate change on epilepsy. Further focussed data would help us to develop evidence for mitigation methods to do more to protect people with epilepsy from the effects of climate change.
AB - Climate change is with us. As professionals who place value on evidence-based practice, climate change is something we cannot ignore. The current pandemic of the novel coronavirus, SARS-CoV-2, has demonstrated how global crises can arise suddenly and have a significant impact on public health. Global warming, a chronic process punctuated by acute episodes of extreme weather events, is an insidious global health crisis needing at least as much attention. Many neurological diseases are complex chronic conditions influenced at many levels by changes in the environment. This review aimed to collate and evaluate reports from clinical and basic science about the relationship between climate change and epilepsy. The keywords climate change, seasonal variation, temperature, humidity, thermoregulation, biorhythm, gene, circadian rhythm, heat, and weather were used to search the published evidence. A number of climatic variables are associated with increased seizure frequency in people with epilepsy. Climate change-induced increase in seizure precipitants such as fevers, stress, and sleep deprivation (e.g. as a result of more frequent extreme weather events) or vector-borne infections may trigger or exacerbate seizures, lead to deterioration of seizure control, and affect neurological, cerebrovascular, or cardiovascular comorbidities and risk of sudden unexpected death in epilepsy. Risks are likely to be modified by many factors, ranging from individual genetic variation and temperature-dependent channel function, to housing quality and global supply chains. According to the results of the limited number of experimental studies with animal models of seizures or epilepsy, different seizure types appear to have distinct susceptibility to seasonal influences. Increased body temperature, whether in the context of fever or not, has a critical role in seizure threshold and seizure-related brain damage. Links between climate change and epilepsy are likely to be multifactorial, complex, and often indirect, which makes predictions difficult. We need more data on possible climate-driven altered risks for seizures, epilepsy, and epileptogenesis, to identify underlying mechanisms at systems, cellular, and molecular levels for better understanding of the impact of climate change on epilepsy. Further focussed data would help us to develop evidence for mitigation methods to do more to protect people with epilepsy from the effects of climate change.
KW - Emergency
KW - Extreme weather events
KW - Global warming
KW - Public health
KW - Seizure
KW - Temperature
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UR - http://www.scopus.com/inward/citedby.url?scp=85100820946&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2021.107791
DO - 10.1016/j.yebeh.2021.107791
M3 - Review article
C2 - 33578223
AN - SCOPUS:85100820946
VL - 116
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
M1 - 107791
ER -